journal article·2017-02-01

Biocatalytic Self-Assembly Using Reversible and Irreversible Enzyme Immobilization

M. P. Conte, K. H. A. Lau, R. V. Ulijn

Publisher page

Abstract

Biocatalytic control of molecular self-assembly provides an effective approach for developing smart biomaterials, allowing versatile enzyme-mediated tuning of material structure and properties as well as enabling biomedical applications. We functionalized surfaces with bioinspired polydopamine and polyphenol coatings to study the effects of enzyme surface localization and surface release on the self-assembly process. We show how these coatings could be conveniently used to release enzymes for bulk gelation as well as to irreversibly immobilize enzymes for localizing the self-assembly to the surface. The results provide insights to the mode of action of biocatalytic self-assembly relevant to nanofabrication and enzyme-responsive materials.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Polymer Surface Interaction Studies · Supramolecular Self-Assembly in Materials · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

WestCHEM/Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom

Advanced Science Research Center (ASRC), City University of New York, 85 St Nicholas Terrace, New York, New York 10027, United States

Department of Chemistry and Biochemistry, City University of New York—Hunter College, 695 Park Avenue, New York, New York 10065, United States

PhD Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States

Funding

Army Research Office · Army Research Laboratory · Seventh Framework Programme

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