journal article·2015-09-02

Sonochemical Synthesis of Hydrophilic Drug Loaded Multifunctional Bovine Serum Albumin Nanocapsules

Zhanfeng Li, Ting Yang, Chunming Lin, Quanshun Li, Songfeng Liu, Fengzhi Xu, Hongyan Wang, Xuejun Cui

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Abstract

A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.
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Research context

OpenAlex topics: Family and Matrimonial Law · Ethics and bioethics in healthcare · Comparative International Legal Studies

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Affiliations

College of Chemistry and ‡College of Life Sciences, Jilin University, Changchun 130012, China

Funding

National Natural Science Foundation of China · Department of Science and Technology of Jilin Province · Graduate Innovation Fund, Jilin University

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