DataVXACS Applied Materials & InterfacesPaper
journal article·2020-03-18Open access

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

Kaouthar Bouzinab, Helen S. Summers, Malcolm F. G. Stevens, Christopher J. Moody, Neil R. Thomas, Pavel Gershkovich, Nicola Weston, Marianne B. Ashford, Tracey D. Bradshaw, Lyudmila Turyanska

ACS Applied Materials & Interfaces· Volume 12· Issue 11
Publisher pageOpen full text
Source abstract

Abstract

-MeG repair conferred by MGMT. We have additionally encapsulated >500 molecules of the N3-propargyl imidazotetrazine analog (N3P), developed to combat TMZ resistance, and demonstrated significantly enhanced activity of AFt-N3P against GBM and colorectal carcinoma cell lines. These studies support the use of AFt as a promising nanodelivery system for targeted delivery, lysosomal drug release, and enhanced imidazotetrazine potency for treatment of GBM and wider-spectrum malignancies.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Iron Metabolism and Disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.

School of Chemistry, University of Nottingham, Nottingham NG7 2RD, U.K.

Biodiscovery Institute, School of Chemistry, University of Nottingham, Nottingham NG7 2RD, U.K.

Nanoscale and Microscale Research Centre, University of Nottingham, Nottingham NG7 2RD, U.K.

Advanced Drug Delivery, Pharmaceutical Sciences, R & D, AstraZeneca, Macclesfield SK10 2NA, U.K.

Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, U.K.

Funding

AstraZeneca · Research Councils UK · University of Nottingham · EPSRC Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines

References (47)

Show source-provided references
1. 10.1126/science.116438210.1126/science.1164382 ↗
2. 10.1016/j.ccr.2006.02.01910.1016/j.ccr.2006.02.019 ↗
3. 10.1073/pnas.071005210410.1073/pnas.0710052104 ↗
4. 10.1016/j.celrep.2016.05.04210.1016/j.celrep.2016.05.042 ↗
5. 10.1038/ncomms519610.1038/ncomms5196 ↗
6. 10.1016/j.ejca.2014.12.01410.1016/j.ejca.2014.12.014 ↗
7. 10.1016/j.neo.2018.05.00110.1016/j.neo.2018.05.001 ↗
8. Baker S. D. · Clin. Cancer Res. · 1999 · 5 · 309
9. 10.1093/neuonc/2.1.4510.1093/neuonc/2.1.45 ↗
10. Newton S. · Cureus · 2018 · 10 · e3329
11. Zhang J. · Curr. Mol. Pharmacol. · 2012 · 5 · 10210.2174/1874467211205010102 ↗
12. 10.1021/bi00197a00310.1021/bi00197a003 ↗
13. 10.1016/0006-2952(87)90351-010.1016/0006-2952(87)90351-0 ↗
14. 10.1101/gad.45540710.1101/gad.455407 ↗
15. 10.3390/ijms2007156210.3390/ijms20071562 ↗
16. 10.1038/sj.onc.120708010.1038/sj.onc.1207080 ↗
17. 10.1093/emboj/cdg21610.1093/emboj/cdg216 ↗
18. 10.1215/15228517-2008-09010.1215/15228517-2008-090 ↗
19. 10.1159/00036613110.1159/000366131 ↗
20. 10.1039/C6MD00384B10.1039/C6MD00384B ↗
21. 10.1016/j.jiec.2019.01.02110.1016/j.jiec.2019.01.021 ↗
22. 10.1093/neuonc/nov16410.1093/neuonc/nov164 ↗
23. 10.1021/am509216510.1021/am5092165 ↗
24. 10.1038/s41598-017-06888-410.1038/s41598-017-06888-4 ↗
25. 10.1098/rstb.1984.004610.1098/rstb.1984.0046 ↗
26. 10.1042/bj133028910.1042/bj1330289 ↗
27. 10.1073/pnas.091319210710.1073/pnas.0913192107 ↗
28. 10.1002/adhm.20150022610.1002/adhm.201500226 ↗
29. 10.1038/312162a010.1038/312162a0 ↗
30. 10.1038/s41598-017-11220-110.1038/s41598-017-11220-1 ↗
31. 10.1080/10717544.2018.146408210.1080/10717544.2018.1464082 ↗
32. 10.3390/ph1104012410.3390/ph11040124 ↗
33. 10.1038/s41598-019-48037-z10.1038/s41598-019-48037-z ↗
34. 10.1016/S0162-0134(99)00114-210.1016/S0162-0134(99)00114-2 ↗
35. 10.1002/elps.20110031010.1002/elps.201100310 ↗
36. 10.1016/0003-2697(76)90527-310.1016/0003-2697(76)90527-3 ↗
37. 10.1002/cnr2.115510.1002/cnr2.1155 ↗
38. 10.1016/j.canlet.2015.10.01310.1016/j.canlet.2015.10.013 ↗
39. Grobmyer S. R. · 2010 · 62410.1007/978-1-60761-609-2_1 ↗
40. 10.1038/nrc349510.1038/nrc3495 ↗
41. 10.20517/cdr.2019.6410.20517/cdr.2019.64 ↗
42. 10.1002/adhm.20150038910.1002/adhm.201500389 ↗
43. 10.1021/acsami.9b1484910.1021/acsami.9b14849 ↗
44. 10.1021/bm200026v10.1021/bm200026v ↗
45. 10.1016/j.jbiomech.2009.09.00310.1016/j.jbiomech.2009.09.003 ↗
46. 10.1016/j.nano.2019.04.00810.1016/j.nano.2019.04.008 ↗
47. 10.1215/15228517-2008-07810.1215/15228517-2008-078 ↗