Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han; Weizhi Wang; Xiangqian Jia; Yixia Qian; Qian Li; Zihua Wang; Weikai Zhang; Shu Yang; Yunhong Jia; Zhiyuan Hu

doi:10.1021/acsami.6b05678

journal article·2016-07-27

Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han, Weizhi Wang, Xiangqian Jia, Yixia Qian, Qian Li, Zihua Wang, Weikai Zhang, Shu Yang, Yunhong Jia, Zhiyuan Hu

ACS Applied Materials & Interfaces· Volume 8· Issue 29

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Source abstract

Abstract

One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China

Medical College, Henan University of Science and Technology, Luoyang, Henan 471003, China

Funding

Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Beijing Municipality

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