Nanohoneycomb Surface-Enhanced Raman Spectroscopy-Active Chip for the Determination of Biomarkers of Hepatocellular Carcinoma
Source abstract
Abstract
Overexpression of the Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) is an essential biomarker for early diagnosis of hepatocellular carcinoma (HCC). In this study, we designed a new surface-enhanced Raman spectroscopy active chip for the detection of AFP with high sensitivity and excellent repeatability. This chip was composed of a honeycomb gold nanostructure array with strong electromagnetic field coupling due to the special cavity geometric characteristics of the honeycomb structure. The honeycomb structure exhibited extraordinary performance for the specific detection of AFP in the range of 0.003-3 ng/mL and also determined the proportion of AFP-L3 with a high degree of accuracy, which has shown great potential for application in the clinical diagnosis of HCC.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Extracellular vesicles in disease · Spectroscopy Techniques in Biomedical and Chemical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Functional Materials Physics and Chemistry, Ministry of Education, College of Physics, Jilin Normal University, Changchun 130103, P.R. China
School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, P.R. China
College of Chemistry, Jilin Normal University, Siping 136000, P.R. China
Funding
National Natural Science Foundation of China · Jilin Development and Reform Commission
References (41)
Show source-provided references
1. International Agency for Research on Cancer, 2014, World Cancer Report 2014: Epidemiology of liver cancer; International Agency for Research on Cancer: Lyon, 2014.
2. 10.3748/wjg.v21.i22.699910.3748/wjg.v21.i22.6999 ↗
3. Trevisani F. · Am. J. Gastroenterol. · 2007 · 102 · 244810.1111/j.1572-0241.2007.01395.x ↗
4. 10.1102/1470-7330.2012.004410.1102/1470-7330.2012.0044 ↗
5. 10.1002/ana.1013610.1002/ana.10136 ↗
6. 10.1186/bcr26610.1186/bcr266 ↗
7. 10.1007/s00261-014-0180-310.1007/s00261-014-0180-3 ↗
8. 10.1016/j.cca.2011.09.01510.1016/j.cca.2011.09.015 ↗
9. 10.1111/j.1572-0241.2006.00467.x10.1111/j.1572-0241.2006.00467.x ↗
10. 10.1046/j.1440-1746.1999.01873.x10.1046/j.1440-1746.1999.01873.x ↗
11. 10.1021/pr700841q10.1021/pr700841q ↗
12. 10.1021/ja108788p10.1021/ja108788p ↗
13. 10.1016/j.bios.2016.03.00910.1016/j.bios.2016.03.009 ↗
14. 10.1016/j.bios.2014.04.02610.1016/j.bios.2014.04.026 ↗
15. 10.1016/j.bios.2015.12.06310.1016/j.bios.2015.12.063 ↗
16. 10.1021/acs.analchem.6b0004810.1021/acs.analchem.6b00048 ↗
17. 10.1021/ac802152b10.1021/ac802152b ↗
18. 10.1016/j.lfs.2005.03.00310.1016/j.lfs.2005.03.003 ↗
19. 10.1021/ja205787410.1021/ja2057874 ↗
20. 10.1039/C8SC00915E10.1039/C8SC00915E ↗
21. 10.1002/anie.20170518710.1002/anie.201705187 ↗
22. 10.1021/jacs.9b0002910.1021/jacs.9b00029 ↗
23. 10.1039/C8SC00727F10.1039/C8SC00727F ↗
24. 10.1016/j.bios.2017.12.04710.1016/j.bios.2017.12.047 ↗
25. 10.1021/acsami.6b0111210.1021/acsami.6b01112 ↗
26. 10.1002/smll.20160228010.1002/smll.201602280 ↗
27. 10.1016/j.isci.2018.11.01710.1016/j.isci.2018.11.017 ↗
28. 10.1002/smll.20170327410.1002/smll.201703274 ↗
29. 10.1021/ac500235510.1021/ac5002355 ↗
30. 10.1039/C5TB02780B10.1039/C5TB02780B ↗
31. 10.1021/ac702390u10.1021/ac702390u ↗
32. 10.1021/acs.analchem.7b0134910.1021/acs.analchem.7b01349 ↗
33. 10.1039/C1CS15155J10.1039/C1CS15155J ↗
34. 10.1039/C8NR10277E10.1039/C8NR10277E ↗
35. 10.1016/j.apsusc.2019.07.18210.1016/j.apsusc.2019.07.182 ↗
36. 10.1016/j.snb.2018.05.13910.1016/j.snb.2018.05.139 ↗
37. 10.1063/1.512060110.1063/1.5120601 ↗
38. 10.1039/C6CP02353C10.1039/C6CP02353C ↗
39. 10.1002/anie.20140764210.1002/anie.201407642 ↗
40. 10.1021/nn300352b10.1021/nn300352b ↗
41. 10.1016/j.jcis.2012.12.03710.1016/j.jcis.2012.12.037 ↗