DataVXACS Applied Materials & InterfacesPaper
journal article·2019-02-27Open access

Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo

Xinglong Yang, Qin Wei, Huawu Shao, Xingyu Jiang

ACS Applied Materials & Interfaces· Volume 11· Issue 8
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Source abstract

Abstract

Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using d-glucosamine (GluN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Bacterial biofilms and quorum sensing · Antimicrobial Peptides and Activities · Antibiotic Resistance in Bacteria

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China

Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China

University of Chinese Academy of Sciences, Beijing 100049, China

CAS Center for Excellence in Nanoscience, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, Beijing Engineering Research Center for BioNanotechnology, National Center for NanoScience and Technology, Beijing 100190, China

Department of Biomedical Engineering, Southern University of Science and Technology, No 1088, Xueyuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518055, China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Shandong Province · Chinese Academy of Sciences

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