Self-Assembled ZnO Nanoparticle Capsules for Carrying and Delivering Isotretinoin to Cancer Cells
Source abstract
Abstract
ZnO@polymer core-shell nanoparticles are assembled into novel capsule shells with diameters of about 100 nm to load isotretinoin (ISO) with a capacity as high as 34.6 wt %. Although ISO, a widely used drug for acne treatment, by itself is not suitable for treating cancer because of its hydrophobicity, our ZnO-ISO composite showed much stronger anticancer activity. The improved cytotoxicity is ascribed to the synergistic effects of the ZnO@polymer and ISO, where the ZnO@polymer helps in the accumulation of ISO in cancer cells on the one hand, and on the other hand, ISO is released completely through ZnO decomposition under acidic conditions of cancer cells. Such a pH-triggered drug-delivery system exhibits a much improved killing of cancer cells in vitro in comparison with the benchmarks, Nintedanib and Crizotinib, two commercial drugs clinically applied against lung cancer.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Photodynamic Therapy Research Studies · Retinoids in leukemia and cellular processes · Acne and Rosacea Treatments and Effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P. R. China
Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200240, P. R. China
Max-Planck Institute of Colloids and Interfaces, Potsdam 14424, Germany
Funding
Ministry of Science and Technology of the People's Republic of China · Shanghai Municipal Education Commission · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China
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