Orthogonally Functionalizable Polyurethane with Subsequent Modification with Heparin and Endothelium-Inducing Peptide Aiming for Vascular Reconstruction

Jun Fang; Jialing Zhang; Jun Du; Yanjun Pan; Jing Shi; Yongxuan Peng; Weiming Chen; Liu Yuan; Sang-Ho Ye; William R. Wagner; Meng Yin; Xiumei Mo

doi:10.1021/acsami.6b04289

journal article·2016-06-15

Orthogonally Functionalizable Polyurethane with Subsequent Modification with Heparin and Endothelium-Inducing Peptide Aiming for Vascular Reconstruction

Jun Fang, Jialing Zhang, Jun Du, Yanjun Pan, Jing Shi, Yongxuan Peng, Weiming Chen, Liu Yuan, Sang-Ho Ye, William R. Wagner, Meng Yin, Xiumei Mo

ACS Applied Materials & Interfaces· Volume 8· Issue 23

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Source abstract

Abstract

Surface coimmobilization modifications of blood-contacting devices with both antithrombogenic moieties and endothelium-inducing biomolecules may create a synergistic effect to improve their performance. However, it is difficult to perform covalent dual-functionalization with both biomolecules on the surface of normally used synthetic polymeric substrates. Herein, we developed and characterized an orthogonally functionalizable polymer, biodegradable elastic poly(ester urethane)urea with disulfide and amino groups (PUSN), which was further fabricated into electropun fibrous scaffolds and surface modified with heparin and endothelial progenitor cells (EPC) recruiting peptide (TPS). The modification effects were assessed through platelet adhesion, EPC, and HUVEC proliferation. Results showed the dual modified PUSN scaffolds demonstrated a synergistic effect of reduced platelet deposition and improved EPC proliferation in vitro study, and demonstrated their potential application in small diameter vascular regeneration.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Materials processing

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Polymer Surface Interaction Studies · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Imaging Diagnosis Center, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States

Funding

Ministry of Education of the People's Republic of China · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Light of Textile Project · Collaborative Innovation Center for Translational Medicine at Shanghai Jiao Tong University School of Medicine

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