journal article·2021-09-08

Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites

Parbeen Singh, Brian Youden, Yikun Yang, Yongli Chen, Andrew Carrier, Shufen Cui, Ken Oakes, Mark Servos, Runqing Jiang, Xu Zhang

ACS Applied Materials & Interfaces· Volume 13· Issue 35
Publisher page

Abstract

Multimodal nanotherapeutic cancer treatments are widely studied but are often limited by their costly and complex syntheses that are not easily scaled up. Herein, a simple formulation of glucose-oxidase-coated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through a synergistic combination of glucose starvation, photothermal therapy, and synergistic advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions that were enhanced by endogenous chloride.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Postdoctoral Innovation Practice Base, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China

Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China

Department of Chemistry, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada

Department of Biology, University of Waterloo, 200 University Ave W, Waterloo, Ontario N2L 3G1, Canada

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China

Department of Biology, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada

Grand River Regional Cancer Centre, 835 King St W, Kitchener, Ontario N2G 1G3, Canada

Funding

Social Sciences and Humanities Research Council of Canada · Government of Guangdong Province · China Postdoctoral Science Foundation · Canada Research Chairs · Cape Breton University · Shenzhen Polytechnic · Natural Sciences and Engineering Research Council of Canada · Canada???s Telus Ride for Dad · Scientific and Technological Foundation of Shenzhen · Prostate Cancer Fight Foundation

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