PEGylated GdF₃:Fe Nanoparticles as Multimodal T₁/T₂-Weighted MRI and X-ray CT Imaging Contrast Agents

Lile Dong; Peng Zhang; Pengpeng Lei; Shuyan Song; Xia Xu; Kaimin Du; Jing Feng; Hongjie Zhang

doi:10.1021/acsami.7b04438

journal article·2017-06-21

PEGylated GdF₃:Fe Nanoparticles as Multimodal T₁/T₂-Weighted MRI and X-ray CT Imaging Contrast Agents

Lile Dong, Peng Zhang, Pengpeng Lei, Shuyan Song, Xia Xu, Kaimin Du, Jing Feng, Hongjie Zhang

ACS Applied Materials & Interfaces· Volume 9· Issue 24

Publisher page

Source abstract

Abstract

Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T 1 / T 2 -weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF 3:Fe nanoparticles (PEG-GdF 3:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T 1 / T 2 -weighted MRI and X-ray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T 1 contrast, evident T 2 contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF 3:Fe NPs. Therefore, PEG-GdF 3:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Lanthanide and Transition Metal Complexes · Medical Imaging Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China

University of Science and Technology of China, Hefei 230026, China

Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, China

University of Chinese Academy of Sciences, Beijing 100049, China

Funding

Ministry of Science and Technology of the People's Republic of China · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · Chinese Academy of Sciences

References (43)

Show source-provided references

1. 10.1002/anie.20140951910.1002/anie.201409519 ↗

2. 10.1039/C4CS00173G10.1039/C4CS00173G ↗

3. 10.1039/C5NR04889C10.1039/C5NR04889C ↗

4. 10.1002/adma.20150608610.1002/adma.201506086 ↗

5. 10.1002/adma.20080236610.1002/adma.200802366 ↗

6. 10.1002/anie.20110668610.1002/anie.201106686 ↗

7. 10.1039/C5NR04065E10.1039/C5NR04065E ↗

8. 10.1039/C4CS00345D10.1039/C4CS00345D ↗

9. 10.1021/cr980440x10.1021/cr980440x ↗

10. 10.1021/cm052299w10.1021/cm052299w ↗

11. 10.1021/ja210260410.1021/ja2102604 ↗

12. 10.1021/acs.chemrev.5b0011210.1021/acs.chemrev.5b00112 ↗

13. 10.1016/j.biomaterials.2014.04.02910.1016/j.biomaterials.2014.04.029 ↗

14. 10.1016/j.biomaterials.2015.11.01010.1016/j.biomaterials.2015.11.010 ↗

15. 10.1002/adfm.20150286810.1002/adfm.201502868 ↗

16. 10.1002/adma.20120316910.1002/adma.201203169 ↗

17. 10.1016/j.biomaterials.2013.03.05810.1016/j.biomaterials.2013.03.058 ↗

18. 10.1016/j.biomaterials.2012.09.01910.1016/j.biomaterials.2012.09.019 ↗

19. 10.1016/j.biomaterials.2013.09.08810.1016/j.biomaterials.2013.09.088 ↗

20. 10.1016/j.biomaterials.2015.10.06310.1016/j.biomaterials.2015.10.063 ↗

21. 10.1002/adfm.20140160910.1002/adfm.201401609 ↗

22. 10.1002/adhm.20120002810.1002/adhm.201200028 ↗

23. 10.1021/cr980441p10.1021/cr980441p ↗

24. 10.1002/adma.20110328910.1002/adma.201103289 ↗

25. 10.1021/cr400478f10.1021/cr400478f ↗

26. 10.1002/adma.20060232610.1002/adma.200602326 ↗

27. 10.1021/acs.chemrev.5b0009110.1021/acs.chemrev.5b00091 ↗

28. 10.1002/adfm.20150367210.1002/adfm.201503672 ↗

29. 10.1002/adfm.20150481010.1002/adfm.201504810 ↗

30. 10.1002/smll.20130082810.1002/smll.201300828 ↗

31. 10.1021/ar500253g10.1021/ar500253g ↗

32. 10.1016/j.biomaterials.2013.11.01810.1016/j.biomaterials.2013.11.018 ↗

33. 10.1021/ja410028q10.1021/ja410028q ↗

34. 10.1002/adma.20110474110.1002/adma.201104741 ↗

35. 10.1039/c3nr01608k10.1039/c3nr01608k ↗

36. 10.1021/ja803688x10.1021/ja803688x ↗

37. 10.1021/ja071471p10.1021/ja071471p ↗

38. 10.1002/adma.20150087010.1002/adma.201500870 ↗

39. 10.1002/smll.20140324910.1002/smll.201403249 ↗

40. 10.1021/nn305991e10.1021/nn305991e ↗

41. 10.1007/s10439-005-9002-710.1007/s10439-005-9002-7 ↗

42. 10.1038/nmat177510.1038/nmat1775 ↗

43. 10.1016/S0169-409X(02)00044-310.1016/S0169-409X(02)00044-3 ↗