DataVXACS Applied Materials & InterfacesPaper
journal article·2015-07-01

Magnetic Hyperthermia Ablation of Tumors Using Injectable Fe3O4/Calcium Phosphate Cement

Chunyan Xu, Yuanyi Zheng, Wei Gao, Jinshun Xu, Guoqing Zuo, Yu Chen, Minzhu Zhao, Jianbo Li, Jinlin Song, Nan Zhang, Zhigang Wang, Hongyun Zhao, Zhechuan Mei

ACS Applied Materials & Interfaces· Volume 7· Issue 25
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Source abstract

Abstract

In this work, we have developed an injectable and biodegradable material using CPC containing Fe3O4 nanoparticles for minimally invasive and efficiently magnetic hyperthermia ablation of tumors. When exposed to an alternating magnetic field, the MCPC could quickly generate heat. The temperature of PBS and the excised bovine liver increased with the MCPC weight, iron content, and time. The ablated liver tissue volume for 0.36 g of 10% MCPC was 0.2 ± 0.03, 1.01 ± 0.07, and 1.96 ± 0.19 cm(3), respectively, at the time point of 60, 180, and 300 s. In our in vivo experiment, the MCPC could be directly injected into the center of the tumors under the guidance of ultrasound imaging. The formed MCPC was well-restricted within the tumor tissues without leakage, and the tumors were completely ablated by 0.36 g of 10% injectable MCPC after 180 s of induction heating.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Ultrasound and Hyperthermia Applications · Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China

State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, PR China

Department of Forensic Medicine, Chongqing Medical University, Chongqing, 400000 PR China

Affiliated Stomatological Hospital of Chongqing Medical University,Chongqing, 400000 PR China

Funding

Chongqing Municipality Education Commission · Chongqing Science Fund for Distinguished Young Scholars · National Natural Science Foundation of China · Program for New Century Excellent Talents in University · Ministry of Education of the People's Republic of China

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