Iron-Based Core–Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy
Source abstract
Abstract
Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal Jeddah 23955-6900, Saudi Arabia
CIC biomaGUNE, Parque Tecnológico de San Sebastián, Paseo Miramón 182, 20014 Donostia-San Sebastián, Spain
Division of Computer, Electrical, and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal Jeddah 23955-6900, Saudi Arabia
iMdea Nanociencia, Campus Universitario de Cantoblanco, C\Faraday, 9, 28049 Madrid, Spain
Nanobiotechnology Unit (iMdea Nanociencia) associated with Centro Nacional de Biotecnología (CNB-CSIC), Campus Universitario de Cantoblanco, Madrid 28049, Spain
Ikerbasque, Basque Foundation for Science, Ma Dı́az de Haro 3, 48013 Bilbao, Spain
Funding
Comunidad de Madrid · Ministerio de Ciencia, Innovaci?n y Universidades · Ministerio de Econom?a, Industria y Competitividad, Gobierno de Espa?a · King Abdullah University of Science and Technology · Eusko Jaurlaritza
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