journal article·2017-06-07

Peptide-Functionalized Nanomaterials for the Efficient Isolation of HER2-Positive Circulating Tumor Cells

Jiaxi Peng, Qiong Zhao, Wangshu Zheng, Wenzhe Li, Ping Li, Ling Zhu, Xiaoran Liu, Bin Shao, Huiping Li, Chen Wang, Yanlian Yang

Publisher page

Abstract

The detection of circulating tumor cells (CTCs) with a specific antigen expression is necessary in therapeutic response monitoring and targeted therapy guidance. The existence of human epidermal growth factor receptor 2 (HER2) and the concentration of HER2-positive CTCs are strong indicators for patient diagnosis, prognosis, and therapeutic monitoring. Herein we report the direct isolation of HER2-positive CTCs by peptide-functionalized nanomaterials. We designed and screened out a peptide as an HER2 antibody alternative demonstrating high HER2 affinity and selectivity. This HER2 recognition peptide bound efficiently with HER2 at the ligand-binding domain. Efficient HER2-positive CTC capture and detection were demonstrated using magnetic nanoparticles functionalized with the HER2 recognition peptide.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cancer Cells and Metastasis · Monoclonal and Polyclonal Antibodies Research · Glycosylation and Glycoproteins Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Renmin University of China, Beijing 100872, China

CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, 52 Fucheng Rd, Beijing 100142, China

University of Chinese Academy of Sciences, Beijing 100049, China

Funding

Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Chinese Academy of Sciences · Key Laboratory of Standardization and Measurement for Nanotechnology, Chinese Academy of Sciences · Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences

References (30)

Show source-provided references
1. 10.1056/NEJMoa04076610.1056/NEJMoa040766 ↗
2. 10.1200/JCO.2005.08.14010.1200/JCO.2005.08.140 ↗
3. 10.1007/s10549-009-0461-710.1007/s10549-009-0461-7 ↗
4. 10.1002/adma.20130008210.1002/adma.201300082 ↗
5. 10.1002/anie.20090166810.1002/anie.200901668 ↗
6. 10.1002/anie.20120845210.1002/anie.201208452 ↗
7. 10.1002/adma.20120523710.1002/adma.201205237 ↗
8. 10.1021/acs.chemrev.5b0032110.1021/acs.chemrev.5b00321 ↗
9. 10.1021/acsami.6b0720510.1021/acsami.6b07205 ↗
10. 10.1021/acsami.7b0114710.1021/acsami.7b01147 ↗
11. 10.1021/acsami.5b0139710.1021/acsami.5b01397 ↗
12. 10.1039/c4tb00456f10.1039/c4tb00456f ↗
13. 10.1038/nnano.2009.33310.1038/nnano.2009.333 ↗
14. 10.1073/pnas.081318810610.1073/pnas.0813188106 ↗
15. 10.18632/oncotarget.668810.18632/oncotarget.6688 ↗
16. 10.1158/1078-0432.CCR-06-169510.1158/1078-0432.CCR-06-1695 ↗
17. 10.1155/2010/61742110.1155/2010/617421 ↗
18. 10.1021/ja307198u10.1021/ja307198u ↗
19. 10.1021/nn201773x10.1021/nn201773x ↗
20. 10.1039/b807500j10.1039/b807500j ↗
21. 10.1002/anie.20130039010.1002/anie.201300390 ↗
22. 10.1093/emboj/19.13.315910.1093/emboj/19.13.3159 ↗
23. 10.1038/sj.onc.120408210.1038/sj.onc.1204082 ↗
24. 10.1038/sj.onc.120677910.1038/sj.onc.1206779 ↗
25. 10.1016/S1535-6108(04)00083-210.1016/S1535-6108(04)00083-2 ↗
26. 10.1038/nature0139210.1038/nature01392 ↗
27. 10.1158/1078-0432.CCR-09-204210.1158/1078-0432.CCR-09-2042 ↗
28. 10.1158/1078-0432.CCR-12-143610.1158/1078-0432.CCR-12-1436 ↗
29. 10.1073/pnas.040299310110.1073/pnas.0402993101 ↗
30. 10.1111/j.1365-2184.2007.00455.x10.1111/j.1365-2184.2007.00455.x ↗