Enhancing Cubosome Functionality by Coating with a Single Layer of Poly-ε-lysine
Source abstract
Abstract
We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-ε-lysine. Poly-ε-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-ε-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Polymer Science and Engineering, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India
Academy of Scientific and Innovative Research, Rafi Marg, New Delhi-110 001, India
Centre for Biomedical Engineering, Indian Institute of Technology—Delhi, Hauz Khas, New Delhi-110016, India
Chemical Engineering Department, Indian Institute of Technology—Bombay, Mumbai-400071, India
Funding
Council for Scientific and Industrial Research · Department of Biotechnology , Ministry of Science and Technology · Department of Science and Technology, Ministry of Science and Technology · University Grants Commission
References (34)
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