In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor

Chaochao Wang; Peiran Zhao; Dawei Jiang; Guoliang Yang; Yudong Xue; Zhongmin Tang; Meng Zhang; Han Wang; Xingwu Jiang; Yelin Wu; Yanyan Liu; Weian Zhang; Wenbo Bu

doi:10.1021/acsami.9b21589

journal article·2020-02-05

In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor

Chaochao Wang, Peiran Zhao, Dawei Jiang, Guoliang Yang, Yudong Xue, Zhongmin Tang, Meng Zhang, Han Wang, Xingwu Jiang, Yelin Wu, Yanyan Liu, Weian Zhang, Wenbo Bu

ACS Applied Materials & Interfaces· Volume 12· Issue 5

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Source abstract

Abstract

The aggregation of hydrophobic photosensitizers limits the therapeutic effect of photodynamic therapy (PDT). Improving the hydrophilicity of photosensitizers can reduce their aggregation for enhancing PDT. Herein, a nanosystem (TPFcNP) is developed by a hydrophobic photosensitizer 5,10,15,20-tetrakis(4-methacryloyloxyphenyl)porphyrin (TMPP) containing multiple carbon–carbon double bonds and a ferrocene-containing amphiphilic block copolymer (PEG-b-PMAEFc), which catalyzes hydrogen peroxide (H2O2) to produce hydroxyl radicals (•OH) in a tumor microenvironment by the Fenton reaction. The •OH could catalyze the addition reaction between the carbon–carbon double bonds of TMPP and overexpressed water-soluble glutathione (GSH) in tumor cells, which greatly improves the hydrophilicity of photosensitizers and reduces their aggregation. Experiments in vitro and in vivo have proved that this strategy significantly enhances the therapeutic efficacy of PDT. Catalyzing intracellular reactions in situ by making use of the tumor microenvironment will open up a new opportunity to solve the aggregation of materials in the tumor for cancer treatment.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Catalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Innovative Microfluidic and Catalytic Techniques Innovation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China

Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China

Funding

the National Funds for Distinguished Young Scientists · the National Key R&D Program of China · the Key Project of Shanghai Science and Technology Commission · the National Natural Science Foundation of China · the National Science Foundation for the Young Scientists of China

References (45)

Show source-provided references

1. 10.1021/cr500419810.1021/cr5004198 ↗

2. 10.1016/j.biomaterials.2018.03.04810.1016/j.biomaterials.2018.03.048 ↗

3. 10.1002/anie.20141141710.1002/anie.201411417 ↗

4. 10.1039/C7CS00594F10.1039/C7CS00594F ↗

5. 10.1021/cr900236h10.1021/cr900236h ↗

6. 10.1039/C4CS00476K10.1039/C4CS00476K ↗

7. 10.1002/anie.20150981010.1002/anie.201509810 ↗

8. 10.1002/anie.20180524610.1002/anie.201805246 ↗

9. 10.1002/anie.20180655110.1002/anie.201806551 ↗

10. 10.1016/j.mencom.2017.09.01310.1016/j.mencom.2017.09.013 ↗

11. 10.1016/0883-9441(89)90011-710.1016/0883-9441(89)90011-7 ↗

12. 10.1021/acs.jpcb.5b0149610.1021/acs.jpcb.5b01496 ↗

13. 10.1021/jacs.8b0865810.1021/jacs.8b08658 ↗

14. 10.1016/j.biomaterials.2016.08.01010.1016/j.biomaterials.2016.08.010 ↗

15. 10.1021/acsami.6b0350210.1021/acsami.6b03502 ↗

16. 10.1021/nn305864210.1021/nn3058642 ↗

17. 10.1002/smll.20160229310.1002/smll.201602293 ↗

18. 10.1002/adfm.20170650710.1002/adfm.201706507 ↗

19. 10.1002/adfm.20170062610.1002/adfm.201700626 ↗

20. 10.1002/adfm.20160425810.1002/adfm.201604258 ↗

21. 10.1021/jacs.7b0555910.1021/jacs.7b05559 ↗

22. 10.1016/j.biomaterials.2017.09.02610.1016/j.biomaterials.2017.09.026 ↗

23. 10.1021/jo901633a10.1021/jo901633a ↗

24. 10.1021/jm010432010.1021/jm0104320 ↗

25. 10.1021/ja01031a01410.1021/ja01031a014 ↗

26. 10.1021/ja207382410.1021/ja2073824 ↗

27. Szatrowski T. P. · Cancer Res. · 1991 · 51 · 794

28. 10.1002/adma.20160190210.1002/adma.201601902 ↗

29. 10.1002/adma.20170483310.1002/adma.201704833 ↗

30. 10.1016/S0304-3894(02)00282-010.1016/S0304-3894(02)00282-0 ↗

31. 10.1080/1064338050032656410.1080/10643380500326564 ↗

32. 10.1016/j.apcatb.2014.09.04710.1016/j.apcatb.2014.09.047 ↗

33. 10.1038/s41467-017-00424-810.1038/s41467-017-00424-8 ↗

34. 10.1016/j.biomaterials.2019.11925410.1016/j.biomaterials.2019.119254 ↗

35. 10.1039/C1CS15157F10.1039/C1CS15157F ↗

36. 10.1002/anie.20090392410.1002/anie.200903924 ↗

37. 10.1021/ja800632510.1021/ja8006325 ↗

38. 10.1002/anie.20151074810.1002/anie.201510748 ↗

39. 10.1002/anie.20160550910.1002/anie.201605509 ↗

40. 10.1021/acs.accounts.5b0040610.1021/acs.accounts.5b00406 ↗

41. 10.1016/j.biomaterials.2015.05.00710.1016/j.biomaterials.2015.05.007 ↗

42. 10.1021/acsami.8b0020710.1021/acsami.8b00207 ↗

43. 10.1039/C4PY01289E10.1039/C4PY01289E ↗

44. 10.1016/j.addr.2010.04.00910.1016/j.addr.2010.04.009 ↗

45. 10.1093/jac/dks37910.1093/jac/dks379 ↗