journal article·2020-02-12

Size-Switchable Nanoparticles with Self-Destructive and Tumor Penetration Characteristics for Site-Specific Phototherapy of Cancer

Kewei Wang, Yalan Tu, Wang Yao, Qingyu Zong, Xuan Xiao, Rui-Meng Yang, Xin-Qing Jiang, Youyong Yuan

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Abstract

The normoxic and hypoxic microenvironments in solid tumors cause cancer cells to show different sensitivities to various treatments. Therefore, it is essential to develop different therapeutic modalities based on the tumor microenvironment. In this study, we designed size-switchable nanoparticles with self-destruction and tumor penetration characteristics for site-specific phototherapy of cancer. This was achieved by photodynamic therapy in the perivascular normoxic microenvironment due to high local oxygen concentrations and photothermal therapy (PTT) in the hypoxic microenvironment, which are not in proximity to blood vessels due to a lack of effective approaches for heat transfer. In brief, a poly(amidoamine) dendrimer with photothermal agent indocyanine green (PAMAM-ICG) was conjugated to the amphiphilic polymer through a singlet oxygen-responsive thioketal linker and then loaded with photosensitizer chlorin e6 (Ce6) to construct a nanotherapy platform (denoted as SNPICG/Ce6). After intravenous injection, SNPICG/Ce6 was accumulated at the perivascular sites of the tumor. The singlet oxygen produced by Ce6 can ablate the tumor cells in the normoxic microenvironment and simultaneously cleave the thioketal linker, allowing the release of small PAMAM-ICGs with improved tumor penetration for PTT in the hypoxic microenvironment. This tailored site-specific phototherapy in normoxic and hypoxic microenvironments provides an effective strategy for cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangzhou First People’s Hospital, School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 510006, P.R. China

Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou 510006, P.R. China

Key Laboratory of Biomedical Engineering of Guangdong Province and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P.R. China

Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P.R. China

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P.R. China

Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, P.R. China

Funding

Ministry of Education of the People's Republic of China · Guangzhou Science and Technology Program key projects · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · ?Thousand Talents Program? for Distinguished Young Scholars · Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory

References (53)

Show source-provided references
1. 10.1002/adhm.20170115610.1002/adhm.201701156 ↗
2. 10.1039/C8SC02408A10.1039/C8SC02408A ↗
3. 10.1038/nrclinonc.2017.16610.1038/nrclinonc.2017.166 ↗
4. 10.1021/acsnano.8b0539910.1021/acsnano.8b05399 ↗
5. 10.1002/anie.20170289810.1002/anie.201702898 ↗
6. 10.1038/nrc306410.1038/nrc3064 ↗
7. 10.1002/adfm.20180422710.1002/adfm.201804227 ↗
8. 10.3389/fphys.2013.0040010.3389/fphys.2013.00400 ↗
9. 10.1126/scitranslmed.aaa126010.1126/scitranslmed.aaa1260 ↗
10. 10.1016/j.ccr.2012.02.02210.1016/j.ccr.2012.02.022 ↗
11. 10.1021/acs.chemrev.7b0025810.1021/acs.chemrev.7b00258 ↗
12. 10.1021/cr500419810.1021/cr5004198 ↗
13. 10.1039/B915149B10.1039/B915149B ↗
14. 10.1039/C4CC09689D10.1039/C4CC09689D ↗
15. 10.1002/adfm.20170650710.1002/adfm.201706507 ↗
16. 10.1002/anie.20150981010.1002/anie.201509810 ↗
17. 10.1002/anie.20180513810.1002/anie.201805138 ↗
18. 10.1039/C6CS00616G10.1039/C6CS00616G ↗
19. 10.1039/C6CS00271D10.1039/C6CS00271D ↗
20. 10.1016/j.biomaterials.2018.08.01110.1016/j.biomaterials.2018.08.011 ↗
21. 10.1016/j.biomaterials.2019.04.02910.1016/j.biomaterials.2019.04.029 ↗
22. 10.1002/smll.20160069710.1002/smll.201600697 ↗
23. 10.1016/j.addr.2016.05.02210.1016/j.addr.2016.05.022 ↗
24. 10.1002/adma.20160299710.1002/adma.201602997 ↗
25. 10.1021/jacs.7b0781810.1021/jacs.7b07818 ↗
26. 10.1002/anie.20170359710.1002/anie.201703597 ↗
27. 10.1021/acsnano.7b0308810.1021/acsnano.7b03088 ↗
28. 10.1269/jrr.21.18010.1269/jrr.21.180 ↗
29. 10.1016/j.canlet.2008.04.02610.1016/j.canlet.2008.04.026 ↗
30. 10.1158/1078-0432.CCR-04-233210.1158/1078-0432.CCR-04-2332 ↗
31. 10.1039/C7NR09552J10.1039/C7NR09552J ↗
32. 10.3109/1073968970914831410.3109/10739689709148314 ↗
33. 10.1073/pnas.152208011310.1073/pnas.1522080113 ↗
34. 10.1002/adma.20160662810.1002/adma.201606628 ↗
35. 10.1002/adfm.20170210810.1002/adfm.201702108 ↗
36. 10.1038/s41565-019-0485-z10.1038/s41565-019-0485-z ↗
37. 10.1002/adfm.20180184010.1002/adfm.201801840 ↗
38. 10.1002/adfm.20170562210.1002/adfm.201705622 ↗
39. 10.1002/adfm.20140448410.1002/adfm.201404484 ↗
40. 10.1002/adma.20170117010.1002/adma.201701170 ↗
41. 10.1038/nnano.2011.16610.1038/nnano.2011.166 ↗
42. 10.1021/acsnano.5b0201710.1021/acsnano.5b02017 ↗
43. 10.1021/acs.nanolett.9b0391310.1021/acs.nanolett.9b03913 ↗
44. 10.1088/0957-4484/20/16/16510110.1088/0957-4484/20/16/165101 ↗
45. 10.1002/mabi.20150044010.1002/mabi.201500440 ↗
46. 10.1002/advs.20160012410.1002/advs.201600124 ↗
47. 10.1002/anie.20120963310.1002/anie.201209633 ↗
48. 10.1002/adfm.20160653010.1002/adfm.201606530 ↗
49. 10.1186/1476-4598-7-1610.1186/1476-4598-7-16 ↗
50. 10.1002/adma.20140155410.1002/adma.201401554 ↗
51. 10.1007/s11095-010-0068-z10.1007/s11095-010-0068-z ↗
52. 10.1021/acs.nanolett.7b0119310.1021/acs.nanolett.7b01193 ↗
53. 10.1002/adma.20170358810.1002/adma.201703588 ↗