Multiplex Analysis on a Single Porous Hydrogel Bead with Encoded SERS Nanotags

Bing Liu; Di Zhang; Haibin Ni; Delong Wang; Liyong Jiang; Degang Fu; Xiaofeng Han; Chi Zhang; Hongyuan Chen; Zhongze Gu; Xiangwei Zhao

doi:10.1021/acsami.7b14942

journal article·2018-01-10

Multiplex Analysis on a Single Porous Hydrogel Bead with Encoded SERS Nanotags

Bing Liu, Di Zhang, Haibin Ni, Delong Wang, Liyong Jiang, Degang Fu, Xiaofeng Han, Chi Zhang, Hongyuan Chen, Zhongze Gu, Xiangwei Zhao

ACS Applied Materials & Interfaces· Volume 10· Issue 1

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Source abstract

Abstract

Bead-based assays have drawn more and more attention in biomedical fields. Herein, we proposed a novel approach to achieve multiplex analysis on a single porous hydrogel bead (PHB) with Raman dyes (RDs) encoded core-shell surface-enhanced Raman scattering (SERS) nanotags. Because of the amplified signal of RDs by core-shell metal structure of the nanotag and the high surface area to volume ratio (SVR) of the PHB, the sensitivity and linear dynamic range (LDR) of the as-proposed multiplex analysis method are significantly improved. We anticipate this approach to be widely used in the multiplex assays and biosensors.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Biosensors and Analytical Detection · Spectroscopy Techniques in Biomedical and Chemical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, School of Science, Nanjing University of Science and Technology, Nanjing 210094, China

Nanjing Institute of Product Quality Inspection, Nanjing 210019, China

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Jiangsu Province · Nanjing Medical University · Jiangsu Science and Technology Department · National Natural Science Foundation of China · Southeast University · Jiangsu Province · Key Laboratory of Environmental Medicine Engineering, Southeast University

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