DataVXACS Applied Materials & InterfacesPaper
journal article·2017-01-11

Antifouling Manganese Oxide Nanoparticles: Synthesis, Characterization, and Applications for Enhanced MR Imaging of Tumors

Peng Wang, Jia Yang, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang, Xiangyang Shi

ACS Applied Materials & Interfaces· Volume 9· Issue 1
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Source abstract

Abstract

Antifouling manganese oxide (Mn 3 O 4 ) nanoparticles (NPs) were synthesized by solvothermal decomposition of tris(2,4-pentanedionato) manganese(III) in the presence of trisodium citrate, followed by surface modification with polyethylene glycol and l -cysteine. The as-prepared nanoparticles have a uniform size distribution, good colloidal stability and good cytocompatibility. The modification of l -cysteine rendered the particles with much longer blood circulation time (half-decay time of 28.4 h) than those without l -cysteine modification (18.5 h), and decreased macrophage cellular uptake. Thanks to desirable antifouling property and relatively high r 1 relaxivity (3.66 mM –1 s –1 ), the l -cysteine-modified Mn 3 O 4 NPs can be used for enhanced tumor magnetic resonance imaging applications.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Lanthanide and Transition Metal Complexes · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People’s Republic of China

Department of Radiology, Department of Ultrasound, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People’s Republic of China

Funding

Deutsche Forschungsgemeinschaft · Shanghai Municipal Education Commission · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China

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