DataVXACS Applied Materials & InterfacesPaper
journal article·2016-11-02

Enhanced Osteogenesis of ADSCs by the Synergistic Effect of Aligned Fibers Containing Collagen I

Hanbang Chen, Yunzhu Qian, Yang Xia, Gang Chen, Yun Dai, Na Li, Feimin Zhang, Ning Gu

ACS Applied Materials & Interfaces· Volume 8· Issue 43
Publisher page
Source abstract

Abstract

The topographical features and material composition of scaffolds have a powerful influence on cell behaviors such as proliferation and differentiation. Here, scaffolds consisting of aligned fibers with incorporated bioactive collagen I were tested for their ability to enhance osteogenesis in vitro. Rat adipose-derived mesenchymal stem cells (ADSCs) were seeded on the scaffolds and their morphology, proliferation, and osteogenic differentiation were examined. Aligned scaffolds with collagen I showed the best osteogenic properties. Also, adhesion-related genes showed the higher expression on aligned scaffolds with collagen I. Our findings indicate that fiber alignment combined with incorporation of collagen I increases the capacity of electrospun scaffolds to induce enhanced and directed osteogenesis. Such scaffolds may, therefore, have potential for improving guided oral bone regeneration.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China

Center of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China

Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China

Suzhou Key Laboratory of Biomaterials and Technologies & Collaborative Innovation Center, Suzhou Nano Science and Technology, Suzhou 215123, China

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Jiangsu Province · Suzhou Municipality · Priority Academic Program Development of Jiangsu Higher Education Institutions · Science and Development Foundation, Nanjing Medical University

References (44)

Show source-provided references
1. 10.1902/jop.2007.07001710.1902/jop.2007.070017 ↗
2. 10.1186/scrt7410.1186/scrt74 ↗
3. 10.1902/jop.2007.06012510.1902/jop.2007.060125 ↗
4. 10.1016/j.ajpath.2011.05.00310.1016/j.ajpath.2011.05.003 ↗
5. 10.1016/j.ijbiomac.2010.03.01510.1016/j.ijbiomac.2010.03.015 ↗
6. 10.1016/j.biomaterials.2011.11.02510.1016/j.biomaterials.2011.11.025 ↗
7. 10.1016/j.actbio.2010.02.03910.1016/j.actbio.2010.02.039 ↗
8. 10.1021/nn402118s10.1021/nn402118s ↗
9. 10.1016/j.stem.2009.06.01610.1016/j.stem.2009.06.016 ↗
10. 10.1089/ten.tea.2013.028210.1089/ten.tea.2013.0282 ↗
11. 10.1089/ten.teb.2011.023510.1089/ten.teb.2011.0235 ↗
12. 10.1002/term.162310.1002/term.1623 ↗
13. 10.1016/j.yexcr.2009.05.01310.1016/j.yexcr.2009.05.013 ↗
14. 10.1088/1748-6041/8/5/05500210.1088/1748-6041/8/5/055002 ↗
15. 10.1016/j.biomaterials.2005.05.08410.1016/j.biomaterials.2005.05.084 ↗
16. 10.1016/j.biomaterials.2007.10.02510.1016/j.biomaterials.2007.10.025 ↗
17. 10.1016/j.biomaterials.2006.01.02210.1016/j.biomaterials.2006.01.022 ↗
18. 10.1002/jbm.a.3216510.1002/jbm.a.32165 ↗
19. 10.1038/nature1140910.1038/nature11409 ↗
20. 10.1016/j.biomaterials.2005.07.00210.1016/j.biomaterials.2005.07.002 ↗
21. 10.1002/term.181110.1002/term.1811 ↗
22. 10.1089/ten.tea.2007.028010.1089/ten.tea.2007.0280 ↗
23. 10.1517/1742524090302573610.1517/17425240903025736 ↗
24. 10.1016/j.biomaterials.2011.10.03010.1016/j.biomaterials.2011.10.030 ↗
25. 10.1089/ten.teb.2010.073810.1089/ten.teb.2010.0738 ↗
26. 10.1016/j.jmbbm.2011.01.00810.1016/j.jmbbm.2011.01.008 ↗
27. 10.1016/j.jsb.2014.07.00110.1016/j.jsb.2014.07.001 ↗
28. 10.1016/S1350-4533(98)00007-110.1016/S1350-4533(98)00007-1 ↗
29. 10.1016/j.nano.2013.04.01310.1016/j.nano.2013.04.013 ↗
30. 10.1038/nprot.2006.43010.1038/nprot.2006.430 ↗
31. 10.1177/088532821351446710.1177/0885328213514467 ↗
32. 10.1177/088391151454305510.1177/0883911514543055 ↗
33. 10.1016/j.actbio.2012.03.02510.1016/j.actbio.2012.03.025 ↗
34. 10.1002/jbm.a.3220810.1002/jbm.a.32208 ↗
35. 10.1007/s10439-004-7825-210.1007/s10439-004-7825-2 ↗
36. 10.1016/j.biomaterials.2009.12.05110.1016/j.biomaterials.2009.12.051 ↗
37. 10.1016/j.biomaterials.2011.08.05410.1016/j.biomaterials.2011.08.054 ↗
38. 10.1016/j.biomaterials.2011.09.09010.1016/j.biomaterials.2011.09.090 ↗
39. 10.1089/ten.2006.12.345910.1089/ten.2006.12.3459 ↗
40. 10.1007/978-3-540-69357-4_510.1007/978-3-540-69357-4_5 ↗
41. 10.1021/am506713910.1021/am5067139 ↗
42. 10.1016/j.colsurfb.2014.08.00510.1016/j.colsurfb.2014.08.005 ↗
43. 10.1021/acsnano.5b0775610.1021/acsnano.5b07756 ↗
44. 10.1021/am504794410.1021/am5047944 ↗