Biomineralization of Stable and Monodisperse Vaterite Microspheres Using Silk Nanoparticles
Source abstract
Abstract
The influence of silk fibroin (SF) on calcium carbonate (CaCO3) biomineralization has been investigated; however, the formation of small, uniform SF-regulated vaterite microspheres has not been reported. In this work, spherical CaCO3 was synthesized via coprecipitation in the presence of SF. SF nanostructures were first tuned by self-assembly at 60 °C to provide better control of the nucleation of CaCO3. Subsequently, monodisperse vaterite microspheres about 1.1 μm were generated by controlling aggregation and growth of CaCO3 under appropriate concentrations of SF and Ca ions. In contrast to unstable vaterite, the microspheres generated in the present study have sufficient stability in aqueous solution for at least 8 days without transformation into calcite, due to the electrostatic interactions between the Ca ions and the preassembled SF nanostructures. The microspheres as drug carriers of doxorubicin (DOX) were assessed and found to have good encapsulation efficiency, sustained drug release without burst release, and pH sensitivity. These new SF/CaCO3 hybrids may provide new options for various biomedical applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Silk-based biomaterials and applications · Bone Tissue Engineering Materials · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People’s Republic of China
Regenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, No. 222 Zhong Shan Road, Dalian 116011, People’s Republic of China
Department of Burns and Plastic Surgery, The Third Affiliated Hospital of Nantong University, Wuxi 214041, People’s Republic of China
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States
Research Center of Materials Science, Beijing Institute of Technology, Beijing, 100081, People’s Republic of China
Funding
Ministry of Science and Technology of the People's Republic of China · National Institute of Dental and Craniofacial Research · National Natural Science Foundation of China · Key Natural Science Foundation of the Jiangsu Higher Education Institutions of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Excellent Youth Foundation of Jiangsu Province
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