DataVXACS Applied Materials & InterfacesPaper
journal article·2017-08-02

Nitric Oxide Nanosensors for Predicting the Development of Osteoarthritis in Rat Model

Pan Jin, Christian Wiraja, Jinmin Zhao, Jinlu Zhang, Li Zheng, Chenjie Xu

ACS Applied Materials & Interfaces· Volume 9· Issue 30
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Source abstract

Abstract

Osteoarthritis (OA) is a chronic arthritic disease that causes the overproduction of inflammatory factors such as nitric oxide (NO). This study develops a NO nanosensor to predict the OA development. The nanosensor is synthesized by encapsulating the NO sensing molecules (i.e., 4-amino-5-methylamino-2′,7′-difluorofluorescein Diaminofluorescein-FM (DAF-FM)) within the biodegradable poly(lactic- co -glycolic acid) nanoparticles. In vitro, the nanosensor allows the monitoring of the NO release in interleukin-1β-stimulated chondrocytes and the alleviated effect of N G -monomethyl- l -arginine (a NO inhibitor) and andrographolide (an anti-inflammatory agent). In the rat OA model, it permits the quantification of NO level in joint fluid. The proposed NO nanosensor may facilitate a noninvasive and real-time evaluation of the OA development.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Chemokine receptors and signaling · Andrographolide Research and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

NTU-Northwestern Institute for Nanomedicine, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore

School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457 Singapore

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Guangxi Province · School of Chemical and Biomedical Engineering, Nanyang Technological University · Scientific Research and Technological Development Foundation of Guangxi Province · High level Innovation Teams and Outstanding Scholars in Guangxi Universities · Northwestern Institute for Nanomedicine, Nanyang Technological University · Lee Kong Chian School of Medicine, Nanyang Technological University

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