Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells
Source abstract
Abstract
The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide- co -glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T 2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Immune Cell Function and Interaction · Immunotherapy and Immune Responses · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States
Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, United States
Funding
National Cancer Institute · National Institute of Biomedical Imaging and Bioengineering · Center for Translational Imaging, Northwestern University · Mouse Histology and Phenotyping Laboratory, Northwestern University
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