Structure–Activity Relationship for Quaternary Ammonium Compounds Hybridized with Poly(methyl methacrylate)
Source abstract
Abstract
Hybrid films from poly (methylmethacrylate) (PMMA) and dioctadecyldimethylammonium bromide (DODAB), cetyltrimethylammonium bromide (CTAB), or tetrapropylammonium bromide (TPAB) were characterized by determination of wettability, ellipsometry, atomic force microscopy, active compounds diffusion to water, X-ray photoelectron spectroscopy (XPS) with determination of atomic composition on the films surface, and biocidal activity against Pseudomonas aeruginosa or Staphylococcus aureus. QAC mobility in the films increased from DODAB to CTAB to TPAB. Diffusion and optimal hydrophobic-hydrophilic balance imparted the highest bioactivity to CTAB. DODAB sustained immobilization at the film surface killed bacteria upon contact. TPAB ability to diffuse was useless because of its unfavorable hydrophobic-hydrophilic balance for bioactivity.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Antimicrobial agents and applications · Bacterial biofilms and quorum sensing · Marine Biology and Environmental Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Biocolloids Lab, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-970, São Paulo/SP, Brazil.
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CEP 05508-900, São Paulo/SP, Brazil.
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo/SP, Caixa Postal 26077, CEP 05513-970, Brazil.
Karlsruhe Institute of Technology (KIT), Institute for Applied Materials (IAM-WPT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany.
References (40)
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