DataVXACS Applied Materials & InterfacesPaper
journal article·2016-12-14

Aptamer-Binding Directed DNA Origami Pattern for Logic Gates

Jing Yang, Shuoxing Jiang, Xiangrong Liu, Linqiang Pan, Cheng Zhang

ACS Applied Materials & Interfaces· Volume 8· Issue 49
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Source abstract

Abstract

In this study, an aptamer-substrate strategy is introduced to control programmable DNA origami pattern. Combined with DNA aptamer-substrate binding and DNAzyme-cutting, small DNA tiles were specifically controlled to fill into the predesigned DNA origami frame. Here, a set of DNA logic gates (OR, YES, and AND) are performed in response to the stimuli of adenosine triphosphate (ATP) and cocaine. The experimental results are confirmed by AFM imaging and time-dependent fluorescence changes, demonstrating that the geometric patterns are regulated in a controllable and programmable manner. Our approach provides a new platform for engineering programmable origami nanopatterns and constructing complex DNA nanodevices.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, China

Department of Chemistry and Biochemistry Center for Molecule Design and Biominetics at the Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States

Department of Computer Science, Xiamen University, Xiamen 361005, China

Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China

Institute of Software, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871, China

Funding

National Natural Science Foundation of China

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