A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells
Source abstract
Abstract
In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a "multi-scale interacting platform" for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO2 nanorod substrates is up to 85%-95%, revealing the potential application of the TiO2 nanorods on efficient and sensitive capture of rare circulating tumor cells.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Cancer Cells and Metastasis · Microfluidic and Bio-sensing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Suzhou 215123, China
State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, School of Pharmacy, Xi’an Jiaotong University, Xi’an 710049, China
Funding
State Administration of Foreign Experts Affairs · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · State Key Laboratory of Electroanalytical Chemistry · Chinese Academy of Sciences
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