journal article·2017-11-29

Zwitterionic Manganese and Gadolinium Metal–Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging

Liang Qin, Zi-Yan Sun, Kai Cheng, Shu-Wen Liu, Jian-Xin Pang, Li-Ming Xia, Wen-Hua Chen, Zhen Cheng, Jin-Xiang Chen

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Abstract

Two water-stable three-dimensional Mn- and Gd-based metal–organic frameworks (MOFs), {[Mn 2 (Cmdcp) 2 (H 2 O) 2 ]·H 2 O} n ( 1 ) and {[Gd(Cmdcp)(H 2 O) 3 ](NO 3 )·3H 2 O} n ( 2, H 3 CmdcpBr = N -(4-carboxy benzyl)-(3,5-dicarboxyl)pyridinium bromide), have been prepared and analyzed. In vitro magnetic resonance imaging indicated that MOFs 1 and 2 possess relaxivity r 1 values of 17.50 and 13.46 mM –1 ·S –1, respectively, which are superior to that of the control Gd-DTPA ( r 1 = 4.87 mM –1 ·S –1, DTPA = diethylene triamine pentaacetate). MOFs 1 and 2 also possessed good biocompatibility and low cytotoxicity against a model cell line. In vivo magnetic resonance images of treated Kunming mice indicated that kidneys showed remarkably positive signal enhancement after 15 min with intravenous administration of MOF 1 and the hyperintensity of both kidneys persisted for about 240 min with no obvious tissue damage. MOF 1 is therefore promising in vivo probes for imaging intravascular diseases and renal dysfunction.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Lanthanide and Transition Metal Complexes · Medical Imaging Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

School of Chemistry and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, China

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China

Department of Radiology, School of Medicine, Stanford University, 1201 Welch Road, Lucas Center, Stanford, California 94305-5484, United States

Funding

Guangdong Science and Technology Department · Biological and Environmental Research · Guangzhou Science and Technology Program key projects · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province

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