DataVXACS Applied Materials & InterfacesPaper
journal article·2016-02-17

Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface

Ying Zhao, Hoi Man Wong, So Ching Lui, Eva Y. W. Chong, Guosong Wu, Xiaoli Zhao, Chong Wang, Haobo Pan, Kenneth M. C. Cheung, Shuilin Wu, Paul K. Chu, Kelvin W. K. Yeung

ACS Applied Materials & Interfaces· Volume 8· Issue 6
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Source abstract

Abstract

This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Metal and Thin Film Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong

Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Province Key Laboratory of Industrial Biotechnology, Faculty of Materials Science and Engineering, Hubei University, Wuhan 430068, China

Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, The University of Hong Kong Shenzhen Hospital, 1 Haiyuan first Road, Futian District, Shenzhen 518053, China

Funding

Research Grants Council, University Grants Committee · AO Foundation · City University of Hong Kong · National Natural Science Foundation of China · Shenzhen Peacock Programs · Guangdong Provincial Science and technology projects

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