journal article·2025-06-04

Janus Gold Nanodiscs with an Asymmetrically Positioned Polyaniline Nano-Urchin for Photothermal Therapy and Multimodal Imaging in the Second Near-Infrared Window

Eun Sook Lee, Jinhyung Lee, Jiwoong Kim, Jueun Kim, Jung-Sub Wi, Ji Yong Park, Tae Geol Lee, Bong Gill Choi, Kyoung G. Lee, Yong-Hoon Kim, Chulhong Kim, Hee-Kyung Na

ACS Applied Materials & Interfaces· Volume 17· Issue 22
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Abstract

The second near-infrared (NIR-II) window (1000-1700 nm) offers advantages in biomedical applications such as deeper tissue penetration and superior imaging contrast. Despite this potential, existing NIR-II probes are limited by biocompatibility concerns, photobleaching, and poor photostability, issues that constrain their clinical utility. This study introduces Janus-type gold nanodiscs having an asymmetrically integrated hierarchical polyaniline (PANI) structure, optimized for use as multifunctional agents for NIR-II photothermal therapy and multimodal imaging. By shifting the localized surface plasmon resonance of the gold nanodiscs─the foundation of the Janus structure─from NIR-I to NIR-II, the developed AuPANI nanodiscs achieve remarkable deep-tissue photoacoustic imaging, up to 15 mm, while also enabling highly sensitive positron emission tomography imaging through stable radiolabeling. The nanodiscs also exhibit superior photostability and notable efficacy as photoacoustic-guided photothermal therapy agents under 1064 nm irradiation. This study positions AuPANI nanodiscs as a versatile platform for NIR-II theranostics, addressing limitations of current probes and advancing their potential for precise and effective cancer treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoplatforms for cancer theranostics · Micro and Nano Robotics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Nanobio Measurement Group, Division of Biomedical Metrology

Korea Research Institute of Standards and Science (KRISS)

Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, Medical Science and Engineering, and Medical Device Innovation Center

POSTECH

Department of Chemical Engineering

Kangwon National University

Department of Materials Science and Engineering

Hanbat National University

Institute of Radiation Medicine, Medical Research Center

Seoul National University College of Medicine

Center for Nano Bio Development

National NanoFab Center (NNFC)

Laboratory Animal Resource Center

Korea Research Institute of Bioscience and Biotechnology (KRIBB)

Department of Functional Genomics

Korea Research Institute of Bioscience and Biotechnology (KRIBB) School of Bioscience, Korea University of Science and Technology (UST)

Funding

Ministry of Education · National Research Council of Science and Technology · Ministry of Science and ICT, South Korea · National Research Foundation of Korea · Korea Research Institute of Standards and Science

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