journal article·2024-06-05

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Xiangli Li, Yingjie Li, Mengxian Du, Yuri V. Petrov, Vladimir E. Baulin, Yujin Wang, Huiping Yuan, Yu Zhou, Baoqiang Li

ACS Applied Materials & Interfaces· Volume 16· Issue 22
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Abstract

Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented synthesis of TPP-CDs and the regulation of TPP linkage modes remain challenges. Herein, we propose a free-radical-initiated random copolymerization in combination with hydrothermal carbonation to regulate the TPP backbone linkage for target-oriented synthesis of triphenylphosphine copolymerization carbon dots (TPP copoly -CDs). The linkage mechanism of random copolymerization reactions is directional, straightforward, and controllable. The TPP content and IC 50 of hydroxyl radicals scavenging ability of TPP copoly -CDs are 53 wt % and 0.52 mg/mL, respectively. TPP serves as a charge control agent to elevate the negatively charged CDs by 20 mV. TPP copoly -CDs with negative charge can target mitochondria, and in the corresponding mechanism the TPP moiety plays a crucial role in targeting mitochondria. This discovery provides a new perspective on the controlled synthesis, TPP linkage modes, and mitochondrial targeting design of TPP-CDs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Electrochemical sensors and biosensors · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute for Advanced Ceramics, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, P. R. China

Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, P. R. China

Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P. R. China

Laboratory of Dynamics and Extreme Characteristics of Promising Nanostructured Materials, Saint Petersburg State University, St. Petersburg 199034, Russia

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Russia

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow 119071, Russia

Funding

Russian Science Foundation · Key Research and Development Program of Heilongjiang · National Natural Science Foundation of China · Interdisciplinary Research Foundation of Harbin Institute of Technology · Ministry of Science and Higher Education of the Russian Federation · Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University · State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology

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