Porous Laser-Scribed Graphene Electrodes Modified with Zwitterionic Moieties: A Strategy for Antibiofouling and Low-Impedance Interfaces

Alanis C. Zambrano; Livia M. D. Loiola; Abdullah Bukhamsin; Radoslaw Gorecki; George Harrison; Veerappan Mani; Shadi Fatayer; Suzana P. Nunes; Khaled N. Salama

doi:10.1021/acsami.3c15849

journal article·2024-01-31Open access

Porous Laser-Scribed Graphene Electrodes Modified with Zwitterionic Moieties: A Strategy for Antibiofouling and Low-Impedance Interfaces

Alanis C. Zambrano, Livia M. D. Loiola, Abdullah Bukhamsin, Radoslaw Gorecki, George Harrison, Veerappan Mani, Shadi Fatayer, Suzana P. Nunes, Khaled N. Salama

ACS Applied Materials & Interfaces· Volume 16· Issue 4

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Abstract

High Resolution Image Download MS PowerPoint Slide Laser-scribed graphene electrodes (LSGEs) are promising platforms for the development of electrochemical biosensors for point-of-care settings and continuous monitoring and wearable applications. However, the frequent occurrence of biofouling drastically reduces the sensitivity and selectivity of these devices, hampering their sensing performance. Herein, we describe a versatile, low-impedance, and robust antibiofouling interface based on sulfobetaine-zwitterionic moieties. The interface induces the formation of a hydration layer and exerts electrostatic repulsion, protecting the electrode surface from the nonspecific adsorption of various biofouling agents. We demonstrate through electrochemical and microscopy techniques that the modified electrode exhibits outstanding antifouling properties, preserving more than 90% of the original signal after 24 h of exposure to bovine serum albumin protein, HeLa cells, and Escherichia coli bacteria. The promising performance of this antifouling strategy suggests that it is a viable option for prolonging the lifetime of LSGEs-based sensors when operating on complex biological systems.

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Research context

Nanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Electrochemical sensors and biosensors · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Bioengineering Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

Environmental Science and Engineering Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

KAUST Solar Center, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

Applied Physics Program, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

Chemistry and Chemical Engineering Programs, Physical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia

Funding

King Abdullah University of Science and Technology

References (64)

Show source-provided references

1. 10.1016/j.susmat.2020.e0020510.1016/j.susmat.2020.e00205 ↗

2. 10.1016/j.bios.2020.11256510.1016/j.bios.2020.112565 ↗

3. 10.1016/j.bios.2021.11311610.1016/j.bios.2021.113116 ↗

4. 10.1002/aelm.20160018510.1002/aelm.201600185 ↗

5. 10.1016/j.bios.2020.11250910.1016/j.bios.2020.112509 ↗

6. 10.1021/acssensors.7b0006610.1021/acssensors.7b00066 ↗

7. 10.1021/acsanm.9b0179510.1021/acsanm.9b01795 ↗

8. 10.1021/nn204200w10.1021/nn204200w ↗

9. 10.1021/acs.accounts.8b0008410.1021/acs.accounts.8b00084 ↗

10. 10.1016/j.carbon.2019.10.00610.1016/j.carbon.2019.10.006 ↗

11. 10.1016/j.bios.2021.11360610.1016/j.bios.2021.113606 ↗

12. 10.1002/adma.20190198110.1002/adma.201901981 ↗

13. 10.1016/j.trechm.2021.09.00110.1016/j.trechm.2021.09.001 ↗

14. 10.1021/acsami.2c0997310.1021/acsami.2c09973 ↗

15. 10.1002/adfm.20221008410.1002/adfm.202210084 ↗

16. 10.1038/s41551-022-00916-z10.1038/s41551-022-00916-z ↗

17. 10.3390/bios1202005510.3390/bios12020055 ↗

18. 10.1007/s00604-021-05157-610.1007/s00604-021-05157-6 ↗

19. 10.1021/acsami.3c0248510.1021/acsami.3c02485 ↗

20. 10.3390/chemosensors1012050510.3390/chemosensors10120505 ↗

21. 10.1002/adsr.20220008810.1002/adsr.202200088 ↗

22. 10.1021/acssensors.1c0039010.1021/acssensors.1c00390 ↗

23. 10.1021/acs.chemrev.9b0073910.1021/acs.chemrev.9b00739 ↗

24. 10.1039/C9AN02017A10.1039/C9AN02017A ↗

25. 10.1038/s41565-019-0566-z10.1038/s41565-019-0566-z ↗

26. 10.3390/ijms2002042310.3390/ijms20020423 ↗

27. 10.1098/rsta.2011.050210.1098/rsta.2011.0502 ↗

28. 10.1021/acsami.2c0969810.1021/acsami.2c09698 ↗

29. 10.1021/acsapm.9b0095010.1021/acsapm.9b00950 ↗

30. 10.3390/chemosensors803006610.3390/chemosensors8030066 ↗

31. 10.1016/j.coche.2020.03.00610.1016/j.coche.2020.03.006 ↗

32. 10.1039/C8AY02674B10.1039/C8AY02674B ↗

33. 10.1039/D0SC03690K10.1039/D0SC03690K ↗

34. 10.1021/acsami.9b0492410.1021/acsami.9b04924 ↗

35. 10.1016/j.actbio.2017.06.03410.1016/j.actbio.2017.06.034 ↗

36. 10.1016/j.jcis.2019.06.04410.1016/j.jcis.2019.06.044 ↗

37. 10.1021/acsami.2c1755710.1021/acsami.2c17557 ↗

38. 10.1021/acs.chemrev.2c0034410.1021/acs.chemrev.2c00344 ↗

39. Fischer M. · 2018 · 16310.1016/B978-0-08-100497-5.00007-0 ↗

40. 10.1021/am400519m10.1021/am400519m ↗

41. 10.1021/acs.biomac.0c0049710.1021/acs.biomac.0c00497 ↗

42. 10.1002/adma.20210789210.1002/adma.202107892 ↗

43. 10.1021/acs.iecr.7b0124110.1021/acs.iecr.7b01241 ↗

44. 10.1021/acsbiomaterials.0c0151710.1021/acsbiomaterials.0c01517 ↗

45. 10.1177/088532821983104410.1177/0885328219831044 ↗

46. 10.1016/j.csbj.2020.07.01510.1016/j.csbj.2020.07.015 ↗

47. 10.1016/j.colsurfb.2004.03.01610.1016/j.colsurfb.2004.03.016 ↗

48. Hermanson G. T. · 2013 · 12710.1016/B978-0-12-382239-0.00002-9 ↗

49. 10.1016/j.apsusc.2022.15368110.1016/j.apsusc.2022.153681 ↗

50. 10.1063/1.10186310.1063/1.101863 ↗

51. Campos Munoz A. · 2023

52. 10.1016/j.electacta.2021.13813210.1016/j.electacta.2021.138132 ↗

53. 10.1038/s42004-019-0254-910.1038/s42004-019-0254-9 ↗

54. 10.1016/j.biomaterials.2011.05.07810.1016/j.biomaterials.2011.05.078 ↗

55. 10.1021/acsami.0c1817210.1021/acsami.0c18172 ↗

56. 10.1111/apm.1267510.1111/apm.12675 ↗

57. 10.2147/NSA.S33448710.2147/NSA.S334487 ↗

58. 10.1021/jacs.6b1122610.1021/jacs.6b11226 ↗

59. 10.1021/la201972f10.1021/la201972f ↗

60. 10.1016/j.carbon.2020.04.09310.1016/j.carbon.2020.04.093 ↗

61. 10.1021/acsami.7b0486310.1021/acsami.7b04863 ↗

62. 10.1039/C4PY01356E10.1039/C4PY01356E ↗

63. 10.1016/j.electacta.2019.13557410.1016/j.electacta.2019.135574 ↗

64. 10.1021/acsomega.1c0366610.1021/acsomega.1c03666 ↗