Nanoparticle-Enabled Zn-0.1Mg Alloy with Long-Term Stability, Refined Degradation, and Favorable Biocompatibility for Biodegradable Implant Devices
Source abstract
Abstract
Zinc-based alloys, specifically Zn–Mg, have garnered considerable attention as promising materials for biodegradable implants due to their favorable mechanical strength, appropriate corrosion rate, and biocompatibility. Nevertheless, the alloy’s lack of mechanical stability and integrity, resulting from ductility loss induced by age hardening at room temperature, hampers its practical bioapplication. In this study, ceramic nanoparticles have been successfully incorporated into the Zn–Mg alloy system, leading to a significant improvement in long-term stability as well as mechanical strength and ductility. In addition, this study represents the first investigation of Zn-based nanocomposites both in vitro and in vivo to comprehend the influence of nanoparticles on the degradation behavior and biocompatibility of the Zn system. The findings indicate that the incorporation of WC nanoparticles effectively refines and stabilizes the degradation behavior of Zn–Mg without negatively impacting the cytocompatibility of the alloy. The subcutaneous implantation and femoral implantation further prove the benefits of nanoparticle incorporation and found no negative effects. Collectively, Zn–Mg–WC nanocomposites yield great potential for implant usage.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Aluminum Alloys Composites Properties · Corrosion Behavior and Inhibition
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California 90024, United States
ZanoMed Inc, Los Angeles, California 90731, United States
Department of Bioengineering, University of California, Los Angeles, California 90024, United States
Department of Biomedical Engineering, the State University of New York at Stony Brook, Stony Brook, New York 11794, United States
Department of Mechanical Design and Production Engineering, Faculty of Engineering, Zagazig University, Zagazig 44519, Egypt
Department of Mechanical and Aerospace Engineering, University of Utah, Salt Lake City, Utah 84112, United States
Fort Wayne Metals, Fort Wayne, Indiana 46809, United States
Department of Material Science and Engineering, University of California, Los Angeles, California 90024, United States
Division of Advanced Prosthodontics, University of California, Los Angeles, California 90024, United States
Department of Orthopedic Surgery, University of California, Los Angeles, California 90024, United States
Funding
National Heart, Lung, and Blood Institute
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