journal article·2023-09-06

A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics

Lihua Li, Zefeng Lin, Xingyi Xu, Wanshun Wang, Hu Chen, Zhibin Feng, Zhongmin Yang, Jianhua Hao

ACS Applied Materials & Interfaces· Volume 15· Issue 35
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Abstract

Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth–manganese core–shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnO x, was designed for 4T1 tumor theranostics in vitro and in vivo . The BDS-GOx@MnO x nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnO x nanozymes have also been systematically studied and revealed.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Future Institute of Technology, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510515, P. R. China

Department of Applied Physics, The Hong Kong Polytechnic University, 999077 Hong Kong, P. R. China

The State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Technology, South China University of Technology, Guangzhou, Guangdong 510640, P. R. China

Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, Orthopedic Center, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, Guangdong, P. R. China

Future Institute of Technology, South China Normal University, Guangzhou 510631, P. R. China

Funding

National Natural Science Foundation of China

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