DataVXACS Applied Materials & InterfacesPaper
journal article·2024-06-05

Deferoxamine-Loaded Injectable Chitosan-Grafted Chlorogenic Acid/Oxidized Hyaluronic Acid Hybrid Hydrogel with Antibacterial, Anti-inflammatory, and Angiogenesis-Promoting Properties for Diabetic Wound Repair

Huiling Zhong, Yifei Fang, Moucheng Luo, Liying Wang, Jun Huang, Gang Dai, Ke Liu, Jun Wu, Jianhang Du

ACS Applied Materials & Interfaces· Volume 16· Issue 22
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Source abstract

Abstract

Diabetic chronic wounds are notoriously difficult to heal as a result of their susceptibility to infection. To address this issue, we constructed an innovated and adaptable solution in the form of injectable chitosan (CS) hydrogel, denoted as CCOD, with enhanced antibacterial and anti-inflammatory properties. This hydrogel is created through a Schiff base reaction that combines chitosan-grafted chlorogenic acid (CS-CGA) and oxidized hyaluronic acid (OHA) with deferoxamine (DFO) as a model drug. The combination of CS and CGA has demonstrated excellent antibacterial and anti-inflammatory properties, while grafting played a pivotal role in making these positive effects stable. These unique features make it possible to customize injectable hydrogel and fit any wound shape, allowing for more effective and personalized treatment of complex bacterial infections. Furthermore, the hydrogel system is not only effective against inflammation and bacterial infections but also possesses antioxidant and angiogenic abilities, making it an ideal solution for the repair of chronic wounds that have been previously thought of as unmanageable.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Medical Research Center, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, People’s Republic of China

School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, Guangdong 518107, People’s Republic of China

Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou, Guangdong 510316, People’s Republic of China

National Health Commission Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, Guangdong 510080, People’s Republic of China

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, People’s Republic of China

The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong 511400, People’s Republic of China

Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong 999077, People’s Republic of China

Funding

Guangdong Provincial Introduction of Innovative Research and Development Team · Science and Technology Planning Project of Shenzen Municipality · National Natural Science Foundation of China · International Science and technology cooperation project of Shenzhen Municipality · Futian District Health Bureau

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