Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids
Source abstract
Abstract
Maintaining the concentrations of various ions in body fluids is critical to all living organisms. In this contribution, we designed a flexible microneedle patch coupled electrode array (MNP-EA) for the in situ multiplexed detection of ion species (Na +, K +, Ca 2+, and H + ) in tissue interstitial fluid (ISF). The microneedles (MNs) are mechanically robust for skin or cuticle penetration (0.21 N/needle) and highly swellable to quickly extract sufficient ISF onto the ion-selective electrochemical electrodes (∼6.87 μL/needle in 5 min). The potentiometric sensor can simultaneously detect these ion species with nearly Nernstian response in the ranges wider enough for diagnosis purposes (Na +: 0.75–200 mM, K +: 1–128 mM, Ca 2+: 0.25–4.25 mM, pH: 5.5–8.5). The in vivo experiments on mice, humans, and plants demonstrate the feasibility of MNP-EA for timely and convenient diagnosis of ion imbalances with minimal invasiveness. This transdermal sensing platform shall be instrumental to home-based diagnosis and health monitoring of chronic diseases and is also promising for smart agriculture and the study of plant biology.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Chemical Sensor Technologies · Analytical Chemistry and Sensors · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637457, Singapore
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
Institute of Flexible Electronics Technology of THU, Jiaxing, Zhejiang 314000, China
Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Skin Research Institute of Singapore, Singapore 308232, Singapore
Lee Kong Chian School of Medicine, Institute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, Singapore
Funding
Ministry of Education - Singapore · National Research Foundation Singapore · Nanyang Technological University · Science and Engineering Research Council
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