Imaging-Guided Biomimetic M1 Macrophage Membrane-Camouflaged Magnetic Nanorobots for Photothermal Immunotargeting Cancer Therapy
Source abstract
Abstract
Biohybrid micro/nanorobots have demonstrated improved therapeutic outcomes for targeting and treating diseases in preclinical trials. However, in vivo applications remain challenging due to a lack of sufficient targeting. Based on evidence that immune cells play a role in the immune modulation in the tumor microenvironment, we developed M1 macrophage membrane-coated magnetic photothermal nanocomplexes (MPN) for photoacoustic (PA) imaging-guided tumor therapy. The MPN were able to inherit the protein from the original macrophage cells and exert a targeted immunosuppression role. Integrating black phosphorus quantum dots and DOX also greatly enhanced reactive oxygen species generation and chemo-phototherapy efficacy. The results suggest that the MPN can be employed as an excellent tumor immunotargeting nanorobotic platform for modulating the tumor microenvironment under PA imaging and magnetic guidance and, thus, exert synergistic therapeutic efficacies.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Micro and Nano Robotics · Nanoplatforms for cancer theranostics · Molecular Communication and Nanonetworks
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Southern University of Science and Technology, Shenzhen 518055, China
Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities, Southern University of Science and Technology, Shenzhen 518055, China
Funding
Science, Technology and Innovation Commission of Shenzhen Municipality · Department of Education of Guangdong Province · Shenzhen Government
References (48)
Show source-provided references
1. 10.1126/scirobotics.aaz951910.1126/scirobotics.aaz9519 ↗
2. 10.1039/C6CS00885B10.1039/C6CS00885B ↗
3. 10.1126/scirobotics.aam643110.1126/scirobotics.aam6431 ↗
4. 10.1007/s40820-019-0350-510.1007/s40820-019-0350-5 ↗
5. 10.1016/j.addr.2017.09.00210.1016/j.addr.2017.09.002 ↗
6. 10.1002/anie.20140609610.1002/anie.201406096 ↗
7. 10.1002/aisy.20210011610.1002/aisy.202100116 ↗
8. 10.1126/scirobotics.aaq049510.1126/scirobotics.aaq0495 ↗
9. 10.1021/acsnano.7b0639810.1021/acsnano.7b06398 ↗
10. 10.1021/acsnano.5b0594010.1021/acsnano.5b05940 ↗
11. 10.1039/C7CS00516D10.1039/C7CS00516D ↗
12. 10.1021/jacs.6b0090210.1021/jacs.6b00902 ↗
13. 10.1021/ja511012v10.1021/ja511012v ↗
14. 10.1016/j.apmt.2017.07.01110.1016/j.apmt.2017.07.011 ↗
15. 10.1002/adma.20170418910.1002/adma.201704189 ↗
16. 10.1021/acs.chemrev.5b0004710.1021/acs.chemrev.5b00047 ↗
17. 10.1021/acsnano.7b0834410.1021/acsnano.7b08344 ↗
18. 10.1126/scirobotics.aaq115510.1126/scirobotics.aaq1155 ↗
19. 10.1002/aisy.20200026710.1002/aisy.202000267 ↗
20. 10.1002/aisy.20200008210.1002/aisy.202000082 ↗
21. 10.1039/D2NR00152G10.1039/D2NR00152G ↗
22. 10.1016/j.matt.2021.10.01010.1016/j.matt.2021.10.010 ↗
23. 10.1021/acs.chemrev.0c0123410.1021/acs.chemrev.0c01234 ↗
24. 10.1016/j.apmt.2017.04.00610.1016/j.apmt.2017.04.006 ↗
25. 10.1126/scirobotics.aat882910.1126/scirobotics.aat8829 ↗
26. 10.1002/adfm.20191039510.1002/adfm.201910395 ↗
27. 10.1021/acs.chemrev.5b0032110.1021/acs.chemrev.5b00321 ↗
28. 10.1002/adma.20170675910.1002/adma.201706759 ↗
29. 10.1016/j.actbio.2020.01.03610.1016/j.actbio.2020.01.036 ↗
30. 10.1002/smll.20180410510.1002/smll.201804105 ↗
31. 10.1002/adfm.20200355910.1002/adfm.202003559 ↗
32. 10.1002/adma.20210717710.1002/adma.202107177 ↗
33. 10.1002/adtp.20180005610.1002/adtp.201800056 ↗
34. 10.1073/pnas.110663410810.1073/pnas.1106634108 ↗
35. 10.1002/adfm.20150105010.1002/adfm.201501050 ↗
36. 10.1002/adfm.20150344110.1002/adfm.201503441 ↗
37. 10.1021/acs.langmuir.5b0476210.1021/acs.langmuir.5b04762 ↗
38. 10.1021/acsami.6b0085310.1021/acsami.6b00853 ↗
39. 10.1002/smll.20160062410.1002/smll.201600624 ↗
40. 10.1002/anie.20170657010.1002/anie.201706570 ↗
41. 10.1021/acsnano.8b0177210.1021/acsnano.8b01772 ↗
42. 10.1016/j.actbio.2021.10.00810.1016/j.actbio.2021.10.008 ↗
43. 10.1146/annurev-immunol-032414-11204310.1146/annurev-immunol-032414-112043 ↗
44. 10.1002/adma.20200205410.1002/adma.202002054 ↗
45. 10.34133/2022/976868710.34133/2022/9768687 ↗
46. 10.1016/j.biomaterials.2020.12015910.1016/j.biomaterials.2020.120159 ↗
47. 10.1021/acs.nanolett.8b0343910.1021/acs.nanolett.8b03439 ↗
48. 10.1021/acsnano.6b0314810.1021/acsnano.6b03148 ↗