DataVXACS Applied Materials & InterfacesPaper
journal article·2023-12-06

Keratin- and VEGF-Incorporated Honey-Based Sponge–Nanofiber Dressing: An Ideal Construct for Wound Healing

Mohamadreza Tavakoli, Marjan Mirhaj, Jaleh Varshosaz, Mastafa H. Al-Musawi, Yasir Q. Almajidi, Amir Mohammad Danesh Pajooh, Mina Shahriari-Khalaji, Fariborz Sharifianjazi, Mansoor Alizadeh, Sheyda Labbaf, Kimia Eslami Shahrebabaki, Pegah Madani Nasab, Mahboubeh Firuzeh, Salar Nasr Esfahani

ACS Applied Materials & Interfaces· Volume 15· Issue 48
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Source abstract

Abstract

To overcome the drawbacks of single-layered wound dressings, bilayer dressings are now introduced as an alternative to achieve effective and long-term treatment. Here, a bilayer dressing composed of electrospun nanofibers in the bottom layer (BL) and a sponge structure as the top layer (TL) is presented. Hydrophilic poly(acrylic acid) (PAAc)-honey (Hny) with interconnected pores of 76.04 μm was prepared as the TL and keratin (Kr), Hny, and vascular endothelial growth factor (VEGF) were prepared as the BL. VEGF indicates a gradual release over 7 days, promoting angiogenesis, as proven by the chick chorioallantoic membrane assay and in vivo tissue histomorphology observation. Additionally, the fabricated dressing material indicated a satisfactory tensile profile, cytocompatibility for human keratinocyte cells, and the ability to promote cell attachment and migration. The in vivo animal model demonstrated that the full-thickness wound healed faster when it was covered with PAAc-Hny/Hny-Kr-VEGF than in other groups. Additionally, faster blood vessel formation, collagen synthetization, and epidermal layer generation were also confirmed, which have proven efficient healing acceleration in wounds treated with synthesized bilayer dressings. Our findings indicated that the fabricated material can be promising as a functional wound dressing.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Silk-based biomaterials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Pharmacy Student’s Research Committee, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran

Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran

Novel Drug Delivery Systems Research Centre, Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran

Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad 10052, Iraq

Department of Pharmacy (Pharmaceutics), Baghdad College of Medical Sciences, Baghdad 10047, Iraq

Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran 1439956191, Iran

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

Department of Natural Sciences, School of Science and Technology, University of Georgia, Tbilisi 0171, Georgia

Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran

Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran

Funding

Isfahan University of Medical Sciences

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