journal article·2021-04-14Open access

A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy

Xiaozhen Li, Di Zhang, Chao Yin, Guihong Lu, Yingpeng Wan, Zhongming Huang, Jihua Tan, Shengliang Li, Jingdong Luo, Chun-Sing Lee

ACS Applied Materials & Interfaces· Volume 13· Issue 14

Abstract

Organic small molecule-based phototheranostics hold great promise for clinical translation by virtue of their distinct chemical structure, easy reproducibility, and high purity. However, reported molecular agents typically have relatively low optical absorbances, particularly over the near-infrared (NIR) region, and this limits their phototheranostic performance. Herein, we first exploit a diradicaloid molecular structure for enhancing NIR absorption to facilitate efficient photoacoustic imaging (PAI)-guided photothermal therapy (PTT). The donor–acceptor interaction in the diradicaloid molecule (DRM) leads to strong charge transfer resulting on obvious diradical characteristics, which is beneficial for NIR absorption. The DRM possesses excellent light-harvesting ability, with a mass extinction coefficient of ∼220 L g–1 cm–1, which is much higher than those (∼5–100 L g–1 cm–1) of typical organic molecules. After assembling into nanoparticles, they show good water dispersibility, good photostability, and impressive performance for PAI-guided PTT in vitro and in vivo. The impressive in vitro and in vivo performances show that developing small molecules with diradicaloid structures can be an effective approach for enhancing NIR harvesting capability for biomedical applications.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P.R. China

Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P.R. China

Shenzhen Research Institute, City University of Hong Kong, Shenzhen 518057, P.R. China

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, P.R. China

National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 1 North 2nd Street, Zhong Guan Cun, Beijing 100190, P.R. China

College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, P.R. China

Funding

Research Grants Council, University Grants Committee · China Postdoctoral Science Foundation · Science, Technology and Innovation Commission of Shenzhen Municipality · Nanjing University of Posts and Telecommunications · City University of Hong Kong · National Natural Science Foundation of China

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