DataVXACS Applied Materials & InterfacesPaper
journal article·2021-06-30

Imaging-Guided Chemo–Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

Zeyu Li, Jiatong Ni, Liping Liu, Liyuan Gu, Zhiguang Wu, Tianlong Li, Krasnyuk Ivan Ivanovich, Wancheng Zhao, Tiedong Sun, Ting Wang

ACS Applied Materials & Interfaces· Volume 13· Issue 25
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Source abstract

Abstract

We demonstrate a versatile nanoparticle with imaging-guided chemo–photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo–photothermal synergistic therapy toward liver cancers in the near future.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Carbon and Quantum Dots Applications · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Forest Plant Ecology, Ministry of Education, Engineering Research Center of Forest Bio-Preparation, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China

Harbin First Specialist Hospital, 217 Hongwei Road, Harbin 150056, China

College of Forestry, Henan Agricultural University, 95 Wenhua Road, Zhengzhou 450002, China

Institute of Pharmacy, Sechenov University, Moscow 119991, Russia

Funding

Natural Science Foundation of Heilongjiang Province · National Natural Science Foundation of China

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