DataVXACS Applied Materials & InterfacesPaper
journal article·2016-06-22

Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy

Hui Gao, Ying Bi, Jun Chen, Lirong Peng, Kaikai Wen, Pan Ji, Weifeng Ren, Xiaoqing Li, Ning Zhang, Jimin Gao, Zhifang Chai, Yi Hu

ACS Applied Materials & Interfaces· Volume 8· Issue 24
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Source abstract

Abstract

Accumulation of nanoparticles in solid tumors depends on their extravasation, but their efficacy is often compromised by intrinsic physiological heterogeneity in tumors. The conventional solutions to circumvent this problem are size control of nanoparticles or increasing the vascular permeability. The aim of this study is to investigate the combination effect of size variation of stimuli-responsive nanoparticles and improved vascular permeability triggered by near-infrared (NIR) light irradiation. Doxorubicin (DOX), a clinically proven drug for bladder cancer, was encapsulated in the nanocomposites with high loading content up to 45%. We show that NIR light-responsive size-switchable nanocarriers could considerably enhance the tumor-targeting of DOX in bladder tumor-bearing mice. Moreover, a combination of NIR-induced hyperthermia and DOX-mediated chemotherapy resulted in remarkable inhibition of tumor growth in mice. Histological results suggest that the change in morphology of tumor microvasculature may account for enhanced extravasation and accumulation of the nanodrugs upon NIR irradiation. Together, these data suggest that external stimuli-responsive drug delivery system offers a safe and effective means of targeted chemo/photothermal therapy.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Cancer, Hypoxia, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

Research Center of Basic Medical Sciences & Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Medical University, Tianjin 300070, China

School of Radiological and Interdisciplinary Sciences, Soochow University, Suzhou 215123, China

Funding

Ministry of Science and Technology of the People's Republic of China · Ministry of Health of the People's Republic of China · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · Chinese Academy of Sciences · Natural Science Foundation of Zhejiang Province · Zhejiang Province

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