journal article·2022-01-12

Functional Macromolecular Adhesives for Bone Fracture Healing

Mingran Zhang, Jiaxue Liu, Tongtong Zhu, Hanxiang Le, Xukai Wang, Jinshan Guo, Guangyao Liu, Jianxun Ding

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Abstract

Compared with traditional internal fixation devices, bone adhesives are expected to exhibit remarkable advantages, such as improved fixation of comminuted fractures and maintained spatial location of fractured scattered bone pieces in treating bone injuries. In this review, different bone adhesives are summarized from the aspects of bone tissue engineering, and the applications of bone adhesives are emphasized. The concepts of "liquid scaffold" and "liquid plate" are proposed to summarize two different research directions of bone adhesives. Furthermore, significant advances of bone adhesives in recent years in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity are discussed. We conclude this topic by providing perspectives on the state-of-the-art research progress and future development trends of bone adhesives. We hope this review will provide a comprehensive summary of bone adhesives and inspire more extensive and in-depth research on this subject.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Surgical Sutures and Adhesives · Polymer Surface Interaction Studies · Hemostasis and retained surgical items

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, People’s Republic of China

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, People’s Republic of China

Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, 5 Jilin Street, Jilin 132000, People’s Republic of China

Orthopaedic Medical Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, People’s Republic of China

Department of Histology and Embryology, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, 1023 Southern Shatai Road, Guangzhou 510515, People’s Republic of China

Funding

National Natural Science Foundation of China · Provincial Health Specific Project of Jilin Province · Youth Innovation Promotion Association of Chinese Academy of Sciences · Specific Project for Health Research Talents of Jilin Province · Science and Technology Development Program of Jilin Province

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