DataVXACS Applied Materials & InterfacesPaper
journal article·2020-08-19

DNA Hydrogel-Based Three-Dimensional Electron Transporter and Its Application in Electrochemical Biosensing

Xiaoxia Mao, Dongsheng Mao, Tianshu Chen, Mohammed Jalalah, Mohammed S. Al-Assiri, Farid A. Harraz, Xiaoli Zhu, Genxi Li

ACS Applied Materials & Interfaces· Volume 12· Issue 33
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Source abstract

Abstract

Electrochemical biosensing relies on electron transport on the electrode surface. However, the limited functional area of the two-dimensional electrode prevents the qualitative breakthrough in the efficiency of electron transfer. Here, a three-dimensional electron transporter was constructed to improve the efficiency of electron transfer by using an interface-immobilized DNA hydrogel. A three-dimensional pure DNA hydrogel is constructed and used as a scaffold for electron transfer. Then, an electron mediator is embedded in the DNA hydrogel through intercalative binding, and DNAzyme with intrinsic peroxidase-like activity is introduced at the node of the hydrogel scaffold to fabricate an electrochemical biosensor. The conduction of the electron mediator in the scaffold enables the acquisition of long-distance DNAzyme catalytic signals, thereby overcoming the limitation of two-dimensional electrodes. This three-dimensional electron transporter is significant for enriching the toolbox of electrochemical biosensing and can provide potential support for the development of highly sensitive biosensors.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersCatalysis & surfaces

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection · Electrochemical sensors and biosensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China

Key Laboratory of Aqueous Environment Protection and Pollution Control of Yangtze River in Anhui of Anhui Provincial Education Department, College of Resources and Environment, Anqing Normal University, Anqing 246011, China

Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, P.O. Box 1988, Najran 11001, Saudi Arabia

Nanomaterials and Nanotechnology Department, Central Metallurgical Research and Development Institute (CMRDI), P.O. 87, Helwan, Cairo 11421, Egypt

State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, China

Funding

Natural Science Foundation of Shanghai · Ministry of Education – Kingdom of Saudi Arabi · National Natural Science Foundation of China

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