journal article·2019-06-12Open access

Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications

Ting Zheng, Parisa Pour Shahid Saeed Abadi, Jungmok Seo, Byung-Hyun Cha, Beatrice Miccoli, Yi-Chen Li, Kijun Park, Sunghyun Park, Seon-Jin Choi, Rasoul Bayaniahangar, Dongxing Zhang, Soo-Hong Lee, Chang-Kee Lee, Ali Khademhosseini, Su Ryon Shin

ACS Applied Materials & Interfaces· Volume 11· Issue 23

Abstract

Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Conducting polymers and applications · Dielectric materials and actuators

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, United States

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China

Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, United States

School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea

Department of Medical Biotechnology, Dongguk University-Seoul, Seoul 04620, Republic of Korea

Department of Electronics and Telecommunications, Politecnico di Torino, Torino 10129, Italy

Korea Packaging Center, Korea Institute of Industrial Technology, Bucheon, Gyeonggi-do 14449, Republic of Korea

Department of Radiology, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California 90095, United States

Centre for Minimally Invasive Therapeutics (C-MIT), University of California–Los Angeles, Los Angeles, California 90095, United States

Funding

Army Research Office · American Association of University Women · American Heart Association · National Institute of Biomedical Imaging and Bioengineering · Harbin Institute of Technology · Brigham Research Institute · China Scholarship Council · National Institute of Arthritis and Musculoskeletal and Skin Diseases · National Institutes of Health · National Science Foundation · Center for Faculty Development & Diversity, Brigham and Women's Hospital

References (54)

Show source-provided references
1. 10.1088/1748-3182/6/4/04500610.1088/1748-3182/6/4/045006 ↗
2. 10.1002/adma.20130343210.1002/adma.201303432 ↗
3. 10.1039/c2jm32256k10.1039/c2jm32256k ↗
4. 10.1016/j.sna.2011.03.02310.1016/j.sna.2011.03.023 ↗
5. 10.1002/adma.20160118610.1002/adma.201601186 ↗
6. 10.1016/S0924-4247(00)00510-010.1016/S0924-4247(00)00510-0 ↗
7. 10.1016/j.sna.2007.03.02410.1016/j.sna.2007.03.024 ↗
8. 10.1021/acsami.5b0959410.1021/acsami.5b09594 ↗
9. 10.1016/S0924-4247(02)00021-310.1016/S0924-4247(02)00021-3 ↗
10. 10.1016/j.talanta.2011.01.00410.1016/j.talanta.2011.01.004 ↗
11. 10.1088/0964-1726/14/1/02010.1088/0964-1726/14/1/020 ↗
12. 10.1016/j.snb.2005.10.04710.1016/j.snb.2005.10.047 ↗
13. 10.1016/j.carbon.2005.02.03610.1016/j.carbon.2005.02.036 ↗
14. 10.1016/j.sna.2010.12.00210.1016/j.sna.2010.12.002 ↗
15. 10.1016/j.jallcom.2011.07.10710.1016/j.jallcom.2011.07.107 ↗
16. 10.1039/b924430a10.1039/b924430a ↗
17. 10.1002/ecj.1023910.1002/ecj.10239 ↗
18. 10.1016/j.matdes.2013.11.08410.1016/j.matdes.2013.11.084 ↗
19. 10.1002/adma.20070077610.1002/adma.200700776 ↗
20. 10.1007/s10008-011-1606-210.1007/s10008-011-1606-2 ↗
21. 10.1021/nl202132m10.1021/nl202132m ↗
22. 10.1080/09243046.2015.108271410.1080/09243046.2015.1082714 ↗
23. 10.1002/adfm.20150137910.1002/adfm.201501379 ↗
24. 10.1002/adma.20110051210.1002/adma.201100512 ↗
25. 10.1021/nn901515j10.1021/nn901515j ↗
26. 10.1002/adma.20110467210.1002/adma.201104672 ↗
27. 10.1021/acs.jpcc.5b1267310.1021/acs.jpcc.5b12673 ↗
28. 10.1002/adma.20060198610.1002/adma.200601986 ↗
29. 10.1016/j.snb.2011.12.06310.1016/j.snb.2011.12.063 ↗
30. 10.1002/adfm.20070082210.1002/adfm.200700822 ↗
31. 10.1021/ja072160h10.1021/ja072160h ↗
32. 10.1021/bc900264710.1021/bc9002647 ↗
33. 10.1103/PhysRevB.65.16542610.1103/PhysRevB.65.165426 ↗
34. 10.1103/PhysRevLett.85.543610.1103/PhysRevLett.85.5436 ↗
35. 10.1002/smll.20090095410.1002/smll.200900954 ↗
36. 10.1016/j.biomaterials.2011.01.00310.1016/j.biomaterials.2011.01.003 ↗
37. 10.1177/204173141772646410.1177/2041731417726464 ↗
38. 10.3390/polym602034610.3390/polym6020346 ↗
39. 10.1016/j.carbpol.2012.10.02810.1016/j.carbpol.2012.10.028 ↗
40. 10.1016/S0141-8130(00)00161-610.1016/S0141-8130(00)00161-6 ↗
41. 10.1016/j.carbpol.2005.05.03510.1016/j.carbpol.2005.05.035 ↗
42. 10.1016/j.ijbiomac.2011.06.01110.1016/j.ijbiomac.2011.06.011 ↗
43. 10.1016/j.polymer.2016.08.01810.1016/j.polymer.2016.08.018 ↗
44. 10.1063/1.487473710.1063/1.4874737 ↗
45. 10.1002/jbm.a.3168110.1002/jbm.a.31681 ↗
46. 10.1016/j.biomaterials.2006.11.05010.1016/j.biomaterials.2006.11.050 ↗
47. 10.1016/j.snb.2009.11.04310.1016/j.snb.2009.11.043 ↗
48. 10.1002/adma.20040107610.1002/adma.200401076 ↗
49. 10.1103/PhysRevB.67.16140110.1103/PhysRevB.67.161401 ↗
50. 10.1002/adma.20070110210.1002/adma.200701102 ↗
51. 10.1021/nn203711s10.1021/nn203711s ↗
52. 10.1016/j.mattod.2015.01.01910.1016/j.mattod.2015.01.019 ↗
53. 10.1016/j.biomaterials.2012.02.03410.1016/j.biomaterials.2012.02.034 ↗
54. 10.1016/j.jaut.2014.05.00310.1016/j.jaut.2014.05.003 ↗