DataVXACS Applied Materials & InterfacesPaper
journal article·2023-10-25

Sequential Anti-Infection and Proangiogenesis of DMOG@ZIF-8/Gelatin-PCL Electrospinning Dressing for Chronic Wound Healing

Lei Yin, Qiwen Tang, Qi Ke, Xinyi Zhang, Jianyu Su, Hua Zhong, Liming Fang

ACS Applied Materials & Interfaces· Volume 15· Issue 42
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Source abstract

Abstract

Bacterial infection and insufficient neovascularization are two major obstacles to the healing of chronic wounds. Here, we present an antibacterial and proangiogenic dressing by encapsulating dimethyloxalylglycine (DMOG) in zeolitic imidazolate framework-8 (ZIF-8) and electrospinning it with gelatin-polycaprolactone (Gel-PCL). As Gel-PCL nanofibers degrade, ZIF-8 nanoparticles decompose, sequentially releasing bactericidal zinc ions and angiogenic DMOG molecules. This cascade process matches the wound-healing stages, ensuring suitable bioavailability and an effective duration of the active components while minimizing their side effects. In vitro, zinc ions released from the dressing (2.5% DMOG@ZIF-8) can eliminate over 90% of Escherichia coli and Staphylococcus aureus without compromising fibroblast cell proliferation and adhesion. In vivo, the dressing can heal skin wounds in Staphylococcus aureus -infected diabetic rats within 2 weeks, facilitated by the DMOG molecules discharged from ZIF-8 (loading rate 21.3%). Immunohistochemical analysis confirmed the regulated expression of factors by zinc ions and DMOG molecules. This work provides new insights into the design of multifunctional dressings for the treatment of chronic wounds.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Diabetic Foot Ulcer Assessment and Management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering, South China University of Technology, Wushan 381, Tianhe District, Guangzhou 510641, China

National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou Higher Education Mega Center, South China University of Technology, Panyu District, Guangzhou 510006, China

China-Singapore International Joint Research Institute, China-Singapore Smart Park, Huangpu District, Guangzhou 510555, China

Department of Orthopaedics, The Fifth Affiliated Hospital, Southern Medical University, Congcheng 566, Conghua District, Guangzhou 510900, China

Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology, Wushan 381, Tianhe District, Guangzhou 510641, China

Funding

Basic and Applied Basic Research Foundation of Guangdong Province · Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing

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