DataVXACS Applied Materials & InterfacesPaper
journal article·2021-02-17

ROS-Responsive Nanoparticle as a Berberine Carrier for OHC-Targeted Therapy of Noise-Induced Hearing Loss

Zeqi Zhao, Zhengzhong Han, Konduru Naveena, Guanxiong Lei, Shiwei Qiu, Xuanyi Li, Ting Li, Xi Shi, Wei Zhuang, Yalan Li, Yuehua Qiao, Hongmei Liu

ACS Applied Materials & Interfaces· Volume 13· Issue 6
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Source abstract

Abstract

Overproduction of reactive oxygen species (ROS) and inflammation are two key pathogeneses of noise-induced hearing loss (NIHL), which leads to outer hair cell (OHC) damage and hearing loss. In this work, we successfully developed ROS-responsive nanoparticles as berberine (BBR) carriers (PL-PPS/BBR) for OHC-targeted therapy of NIHL: Prestin-targeting peptide 2 (PrTP2)-modified nanoparticles (PL-PPS/BBR), which effectively accumulated in OHC areas, and poly(propylene sulfide)120 (PPS120), which scavenged ROS and converted to poly(propylene sulfoxide)120 in a ROS environment to disintegrate and provoke the rapid release of BBR with anti-inflammatory and antioxidant effects. In this study, satisfactory anti-inflammatory and antioxidant effects of PL-PPS/BBR were confirmed. Immunofluorescence and scanning electron microscopy (SEM) images showed that PL-PPS/BBR effectively accumulated in OHCs and protected the morphological integrity of OHCs. The auditory brainstem response (ABR) results demonstrated that PL-PPS/BBR significantly improved hearing in NIHL guinea pigs after noise exposure. This work suggested that PL-PPS/BBR may be a new potential treatment for noise-associated injury with clinical application.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Berberine and alkaloids research · Ion Channels and Receptors · Bioactive natural compounds

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Audiology and Balance Science, Xuzhou Medical University, Xuzhou 221002, PR China

Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, PR China

Artificial Auditory Laboratory of Jiangsu Province, Xuzhou Medical University, Xuzhou 221002, PR China

Xuzhou Children’s Hospital, Xuzhou 221002, PR China

Key Laboratory of Medical Imaging and Artifical Intelligence of Hunan Province, Xiangnan University, Chenzhou 423000, PR China

Clinical College, Xiangnan University, Chenzhou 423000, PR China

Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, PR China

Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, PR China

Funding

National Natural Science Foundation of China · Social Development Project of Xuzhou Department of Science and Technology · Jiangsu Scientific Research and Innovation for Postgraduates · the Youth Science and Technology Innovation Team of Xuzhou Medical University · Excellent Youth Foundation of Hunan Education Department · Xuzhou Key R&D Program (Social Development) · Natural Science Foundation of the Jiangsu Higher Education Institutions of China · Special Fund for Clinical Scientific Research of Jieping Wu Foundation

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