DataVXACS Applied Materials & InterfacesPaper
journal article·2020-12-23

Iron-Mineralization-Induced Mesoporous Metal–Organic Frameworks Enable High-Efficiency Synergistic Catalysis of Natural/Nanomimic Enzymes

Siming Huang, Guosheng Chen, Niru Ye, Xiaoxue Kou, Rui Zhang, Jun Shen, Gangfeng Ouyang

ACS Applied Materials & Interfaces· Volume 12· Issue 51
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Source abstract

Abstract

Metal-organic frameworks (MOFs) have become a promising accommodation for enzyme immobilization and protection. However, the integration of multienzymes into MOFs may result in compromise of individual enzymatic activity. In this work, we report an iron mineralization strategy to facilely construct a mesoporous MOF, possessing excellent peroxidase-mimic bioactivity. Furthermore, the feasibility of in situ encapsulating natural enzymes within the developed mesoporous MOF nanozymes endows these natural/nanomimic enzyme hybrids with remarkably enhanced synergistic catalysis ability. Such activity enhancement is mainly due to (1) the fast flux rate of substances through the interconnected mesoporous channels and (2) the simultaneously increased loading amount of enzymes and iron within the MOFs caused by the iron mineralization process.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Metal-Organic Frameworks: Synthesis and Applications · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

MOE Key Laboratory of Bioinorganic and Synthetic ChemistrySchool of Chemistry, Sun Yat-sen University, Guangzhou 510275, China

Department of Biliary-Pancreas Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Guangdong Basic and Applied Basic Research Foundation · Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme · Key Areas Research and Development Program of Guangdong

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