DataVXACS Applied Materials & InterfacesPaper
journal article·2023-02-15

Mild Heat-Assisted Polydopamine/Alginate Hydrogel Containing Low-Dose Nanoselenium for Facilitating Infected Wound Healing

Jinfeng Xu, Muhammad Rizwan Younis, Zhaowenbin Zhang, Yanping Feng, Lefeng Su, Yumei Que, Yiren Jiao, Chen Fan, Jiang Chang, Siyu Ni, Chen Yang

ACS Applied Materials & Interfaces· Volume 15· Issue 6
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Source abstract

Abstract

In clinical practice, it has become urgent to develop multifunctional wound dressings that can combat infection and prompt wound healing simultaneously. In this study, we proposed a polydopamine/alginate/nanoselenium composite hydrogel (Alg-PDA-Se) for the treatment of infected wounds. In particular, polydopamine endows the composite hydrogel with controllable near-infrared photothermal properties, while low-dosage selenium nanoparticles (Se NPs) offer excellent anti-oxidation, anti-inflammatory, pro-proliferative, pro-migration, and pro-angiogenic performances, which are verified by multiple cells, including macrophages, fibroblasts, and endothelial cells. More interestingly, the combination of mild temperature with low-dosage Se NPs produces a synergistic effect on combating both Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) and promoting the healing of bacteria-infected wounds in vivo. We anticipate that the designed composite hydrogel might be a potential candidate for anti-infection bioactive dressing.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterialsComposites

OpenAlex topics: Wound Healing and Treatments · Corneal Surgery and Treatments · Advancements in Transdermal Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Biological Science and Medical Engineering, Donghua University, Shanghai201620, China

Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou325000, China

Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen518060, China

Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou325000, China

Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai200050, China

Funding

Natural Science Foundation of Shanghai · Wenzhou Medical University · National Natural Science Foundation of China · Wenzhou Science and Technology Project · Wenzhou Science and Technology Major Project · Wenzhou Institute, University of Chinese Academy of Sciences · Zhejiang Engineering Research Center for Tissue Repair Materials

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