DataVXACS Applied Materials & InterfacesPaper
journal article·2021-04-07Open access

Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria

Diana Vilela, Nuria Blanco-Cabra, Ander Eguskiza, Ana C. Hortelao, Eduard Torrents, Samuel Sanchez

ACS Applied Materials & Interfaces· Volume 13· Issue 13
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Source abstract

Abstract

High Resolution Image Download MS PowerPoint Slide The low efficacy of current conventional treatments for bacterial infections increases mortality rates worldwide. To alleviate this global health problem, we propose drug-free enzyme-based nanomotors for the treatment of bacterial urinary-tract infections. We develop nanomotors consisting of mesoporous silica nanoparticles (MSNPs) that were functionalized with either urease (U-MSNPs), lysozyme (L-MSNPs), or urease and lysozyme (M-MSNPs), and use them against nonpathogenic planktonic Escherichia coli . U-MSNPs exhibited the highest bactericidal activity due to biocatalysis of urea into NaHCO 3 and NH 3, which also propels U-MSNPs. In addition, U-MSNPs in concentrations above 200 μg/mL were capable of successfully reducing 60% of the biofilm biomass of a uropathogenic E. coli strain. This study thus provides a proof-of-concept, demonstrating that enzyme-based nanomotors are capable of fighting infectious diseases. This approach could potentially be extended to other kinds of diseases by selecting appropriate biomolecules.
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Research context

Nanomaterials

OpenAlex topics: Micro and Nano Robotics · Molecular Communication and Nanonetworks · Photoreceptor and optogenetics research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Smart nano-bio-devices, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10-12, 08028 Barcelona Spain

Bacterial infections: antimicrobial therapies, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10-12, 08028 Barcelona Spain

Microbiology Section, Department of Genetics, Microbiology and Statistics Faculty of Biology, University of Barcelona, 643 Diagonal Ave., 08028 Barcelona, Spain

Institució Catalana de Recerca i Estudis Avancats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain

Funding

Fundaci?n BBVA · Ministerio de Ciencia, Innovaci?n y Universidades · European Regional Development Fund · Ministerio de Econom?a y Competitividad · ?la Caixa? Foundation · H2020 Marie Sklodowska-Curie Actions · H2020 European Research Council · Comissi? Interdepartamental de Recerca i Innovaci? Tecnol?gica · CERCA programme/Generalitat de Catalunya · Agencia Estatal de Investigaci?n

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