journal article·2019-09-11

Synthesis and Imaging of Biocompatible Graphdiyne Quantum Dots

Huan Min, Yingqiu Qi, Yanhuan Chen, Yinlong Zhang, Xuexiang Han, Ying Xu, Ying Liu, Jianshe Hu, Hiubiao Liu, Yiye Li, Guangjun Nie

ACS Applied Materials & Interfaces· Volume 11· Issue 36
Publisher page

Abstract

Graphdiyne has attracted much interest from researchers for their potential applications in energy storage, catalysis, and biomedical areas. As one of the derivatives of graphdiyne, graphdiyne quantum dots (GDQDs) may possess superior bioactivity due to active acetylene units. However, the biological application of biocompatible GDQDs have not been reported so far. Herein, GDQDs with uniform size and good crystallization were prepared via a classical solvothermal method. The GDQDs exhibit excitation- and pH-dependent fluorescence emission as well as superior photostability, demonstrating their potential for bioimaging. The GDQDs demonstrate efficient cellular uptake and cell imaging without induction of detectable cytotoxic effects in vitro. Systematical safety evaluation further confirmed good biocompatibility of the GDQDs in vivo. Our study preliminarily validates the application of the GDQDs in biomedicine and encourages more thorough studies for better realizing the potential of GDQDs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Nanocluster Synthesis and Applications · Quantum Dots Synthesis And Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Science, Northeastern University, Shenyang 110819, P. R. China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China

School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China

CAS Key Laboratory of Organic Solids, Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Sino-Danish College, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS · Innovation Group of the National Natural Science Foundation of China · National Science Fund for Excellent Young Scholars

References (43)

Show source-provided references
1. 10.1038/nmat308710.1038/nmat3087 ↗
2. 10.1039/C4CS00448E10.1039/C4CS00448E ↗
3. 10.1021/acs.chemrev.6b0055810.1021/acs.chemrev.6b00558 ↗
4. 10.1038/nchem.90710.1038/nchem.907 ↗
5. 10.1039/C2CS35342C10.1039/C2CS35342C ↗
6. 10.1021/acs.chemrev.6b0052010.1021/acs.chemrev.6b00520 ↗
7. 10.1039/C4CS00269E10.1039/C4CS00269E ↗
8. 10.1002/smll.20140264810.1002/smll.201402648 ↗
9. 10.1002/smll.20110170610.1002/smll.201101706 ↗
10. 10.1002/anie.20170598910.1002/anie.201705989 ↗
11. 10.1039/c1cc11122a10.1039/c1cc11122a ↗
12. 10.1007/s12274-014-0644-310.1007/s12274-014-0644-3 ↗
13. 10.1002/adma.20120193010.1002/adma.201201930 ↗
14. 10.1002/adma.20090282510.1002/adma.200902825 ↗
15. 10.1021/nn501640q10.1021/nn501640q ↗
16. 10.1038/ncomms559610.1038/ncomms5596 ↗
17. 10.1002/adma.20150032310.1002/adma.201500323 ↗
18. 10.1039/C4NR05712K10.1039/C4NR05712K ↗
19. 10.1039/b922733d10.1039/b922733d ↗
20. 10.1021/acsami.8b0311810.1021/acsami.8b03118 ↗
21. 10.1038/s41467-018-03896-410.1038/s41467-018-03896-4 ↗
22. 10.1016/j.carbon.2018.02.10710.1016/j.carbon.2018.02.107 ↗
23. 10.1021/ja513133710.1021/ja5131337 ↗
24. 10.1002/adfm.20160157010.1002/adfm.201601570 ↗
25. 10.1021/acs.accounts.7b0020510.1021/acs.accounts.7b00205 ↗
26. 10.1039/C6CC01856D10.1039/C6CC01856D ↗
27. 10.1021/acs.chemmater.7b0196510.1021/acs.chemmater.7b01965 ↗
28. 10.1021/acsami.7b1721910.1021/acsami.7b17219 ↗
29. 10.1021/acsami.8b0094910.1021/acsami.8b00949 ↗
30. 10.1021/am300253c10.1021/am300253c ↗
31. 10.1021/ja206030c10.1021/ja206030c ↗
32. 10.1002/anie.20130111410.1002/anie.201301114 ↗
33. 10.1039/C4NR04267K10.1039/C4NR04267K ↗
34. 10.1021/jacs.6b1277610.1021/jacs.6b12776 ↗
35. 10.1016/j.msec.2013.03.01810.1016/j.msec.2013.03.018 ↗
36. 10.1021/nl203897910.1021/nl2038979 ↗
37. 10.1021/nl400368v10.1021/nl400368v ↗
38. 10.1021/acsnano.7b0817210.1021/acsnano.7b08172 ↗
39. 10.1016/j.ijpharm.2009.07.02310.1016/j.ijpharm.2009.07.023 ↗
40. 10.1002/adhm.20130006610.1002/adhm.201300066 ↗
41. 10.1016/j.toxlet.2015.05.02110.1016/j.toxlet.2015.05.021 ↗
42. 10.1002/adma.20120267810.1002/adma.201202678 ↗
43. 10.1021/acs.chemrev.8b0028810.1021/acs.chemrev.8b00288 ↗