Pillar[6]arene-Valved Mesoporous Silica Nanovehicles for Multiresponsive Controlled Release

The synthesis and host-guest chemistry of pillararene (PA) derivatives are a hot research topic, and the applications of PAs in relevant research fields are essential to explore. Carboxylate-substituted pillar[6]arene (CPA[6])-valved mesoporous silica nanoparticles (MSNs) functionalized with dimethylbenzimidazolium (DMBI) and bipyridinium (BP) stalks were constructed, respectively, for multiresponsive controlled release. CPA[6] encircled the DMBI or BP stalks to develop supramolecular nanovalves for encapsulation of cargo within the MSN pores. The release of cargo was triggered by acidic pH or competitive binding for the dethreading of CPA[6] and the opening of the nanovalves; moreover, coordination chemistry is the first strategy to activate CPA nanovalves by metal chelating with the carboxylate groups of CPA for cargo release. The controlled release of the CPA[6]-valved MSN delivery systems can meet diverse requirements and has promising biological applications in targeted drug therapy.