DataVXACS Applied Materials & InterfacesPaper
journal article·2021-12-08

pH-Responsive Multifunctional Theranostic Rapamycin-Loaded Nanoparticles for Imaging and Treatment of Acute Ischemic Stroke

Yan Cheng, Airong Cheng, Yanlong Jia, Lin Yang, Yan Ning, Liang Xu, Yazhi Zhong, Zerui Zhuang, Jitian Guan, Xiaolei Zhang, Yan Lin, Teng Zhou, Xiusong Fan, Jianwu Li, Peng Liu, Gen Yan, Renhua Wu

ACS Applied Materials & Interfaces· Volume 13· Issue 48
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Source abstract

Abstract

Stroke is the second leading cause of death globally and the most common cause of severe disability. Several barriers need to be addressed more effectively to treat stroke, including efficient delivery of therapeutic agents, rapid release at the infarct site, precise imaging of the infarct site, and drug distribution monitoring. The present study aimed to develop a bio-responsive theranostic nanoplatform with signal-amplifying capability to deliver rapamycin (RAPA) to ischemic brain tissues and visually monitor drug distribution. A pH-sensitive theranostic RAPA-loaded nanoparticle system was designed since ischemic tissues have a low-pH microenvironment compared with normal tissues. The nanoparticles demonstrated good stability and biocompatibility and could efficiently load rapamycin, followed by its rapid release in acidic environments, thereby improving therapeutic accuracy. The nano-drug-delivery system also exhibited acid-enhanced magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging signal properties, enabling accurate multimodal imaging with minimal background noise, thus improving drug tracing and diagnostic accuracy. Finally, in vivo experiments confirmed that the nanoparticles preferentially aggregated in the ischemic hemisphere and exerted a neuroprotective effect in rats with transient middle cerebral artery occlusion (tMCAO). These pH-sensitive multifunctional theranostic nanoparticles could serve as a potential nanoplatform for drug tracing as well as the treatment and even diagnosis of acute ischemic stroke. Moreover, they could be a universal solution to achieve accurate in vivo imaging and treatment of other diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology, The Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, China

Department of Neurology, Chengwu County People’s Hospital, Chengwu 274200, Shandong, China

Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei 441021, China

Department of TCM, Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University, Shenzhen 518028, Guangdong, China

Department of Neurosurgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

Department of Neurosurgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou 515041, Guangdong, China

Department of Neurosurgery, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong, China

Department of Computer Science, Shantou University, Shantou 515041, China

Department of Radiology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China

Transfusion Department, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China

National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China

Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen 361023, Fujian, China

Funding

National Natural Science Foundation of China · Guangdong High-Level University Development Program · 2020 Li Ka Shing Foundation Cross-Disciplinary Research · 2020 LKSF Cross-Disciplinary Research · Shenzhen Science and Technology Program

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